CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8

Amino Acid Sequence Animals CD8 Antigens / chemistry CD8-Positive T-Lymphocytes / immunology Histocompatibility Antigens / chemistry Lymphocyte Activation / immunology Mice Mice, Knockout Models, Biological Models, Molecular Multiprotein Complexes / chemistry Mutation Peptides / chemistry Protein Binding Protein Conformation Protein Interaction Domains and Motifs Structure-Activity Relationship
CD8 MHC Structure T cell T-cell receptor

Journal

Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R

Informations de publication

Date de publication:
06 12 2019
Historique:
received: 02 07 2019
revised: 21 10 2019
accepted: 23 10 2019
pubmed: 11 11 2019
medline: 17 6 2020
entrez: 10 11 2019
Statut: ppublish

Résumé

The coreceptor CD8αβ can greatly promote activation of T cells by strengthening T-cell receptor (TCR) binding to cognate peptide-MHC complexes (pMHC) on antigen presenting cells and by bringing p56

Identifiants

DOI: 10.1016/j.jmb.2019.10.019 PMID: 31704286
pubmed: 31704286
pii: S0022-2836(19)30615-1
doi: 10.1016/j.jmb.2019.10.019
pii:
doi:

Substances chimiques

CD8 Antigens 0
Histocompatibility Antigens 0
Multiprotein Complexes 0
Peptides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4941-4958

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Yang Liu (Y)

Ludwig Institute for Cancer Research, University of Lausanne, and Department of Oncology, University Hospital of Lausanne, 1009, Lausanne, Switzerland.

Michel A Cuendet (MA)

Ludwig Institute for Cancer Research, University of Lausanne, and Department of Oncology, University Hospital of Lausanne, 1009, Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, USA.

Laurence Goffin (L)

Ludwig Institute for Cancer Research, University of Lausanne, and Department of Oncology, University Hospital of Lausanne, 1009, Lausanne, Switzerland.

Radek Šachl (R)

Department of Biophysical Chemistry, J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences, 18223 Prague, Czech Republic.

Marek Cebecauer (M)

Department of Biophysical Chemistry, J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences, 18223 Prague, Czech Republic.

Luca Cariolato (L)

Ludwig Institute for Cancer Research, University of Lausanne, and Department of Oncology, University Hospital of Lausanne, 1009, Lausanne, Switzerland.

Philippe Guillaume (P)

Ludwig Institute for Cancer Research, University of Lausanne, and Department of Oncology, University Hospital of Lausanne, 1009, Lausanne, Switzerland.

Patrick Reichenbach (P)

Ludwig Institute for Cancer Research, University of Lausanne, and Department of Oncology, University Hospital of Lausanne, 1009, Lausanne, Switzerland.

Melita Irving (M)

Ludwig Institute for Cancer Research, University of Lausanne, and Department of Oncology, University Hospital of Lausanne, 1009, Lausanne, Switzerland.

George Coukos (G)

Ludwig Institute for Cancer Research, University of Lausanne, and Department of Oncology, University Hospital of Lausanne, 1009, Lausanne, Switzerland.

Immanuel F Luescher (IF)

Ludwig Institute for Cancer Research, University of Lausanne, and Department of Oncology, University Hospital of Lausanne, 1009, Lausanne, Switzerland. Electronic address: immanuel.luescher@unil.ch.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Eucaryotes › Animaux › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD8 › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Motifs et domaines d'intéraction protéique › CD8 Binding of MHC-Peptide Complexes in cis or...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › CD8 Binding of MHC-Peptide Complexes in cis or...