Absence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY: Lessons From a 5-Year Pediatric Swedish National Cohort Study.
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
15
04
2019
accepted:
19
10
2019
pubmed:
11
11
2019
medline:
3
10
2020
entrez:
10
11
2019
Statut:
ppublish
Résumé
Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. We aimed to identify the discriminatory clinical features at diabetes diagnosis of patients with glucokinase (GCK), hepatocyte nuclear factor-1A (HNF1A), and HNF4A MODY in the pediatric population. Swedish patients ( The minimal prevalence of MODY was 1.2%. Discriminatory factors for MODY at diagnosis included four islet autoantibody negativity (100% vs. 11% not-known MODY; At diagnosis of pediatric diabetes, absence of all islet autoantibodies and modest hyperglycemia (HbA
Identifiants
pubmed: 31704690
pii: dc19-0747
doi: 10.2337/dc19-0747
pmc: PMC6925576
doi:
Substances chimiques
Autoantibodies
0
Blood Glucose
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-89Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : U01 DK063861
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK063861
Pays : United States
Organisme : Wellcome Trust
ID : 098395/Z/12/Z
Pays : United Kingdom
Informations de copyright
© 2019 by the American Diabetes Association.
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