Assessment of Outcome of Hepatic Resection for Extremely Elderly Patients With a Hepatic Malignancy.
Age Factors
Aged
Aged, 80 and over
Analysis of Variance
Carcinoma, Hepatocellular
/ mortality
Colorectal Neoplasms
/ pathology
Comorbidity
Disease-Free Survival
Female
Hepatectomy
/ mortality
Hospital Mortality
Humans
Kaplan-Meier Estimate
Liver Neoplasms
/ mortality
Male
Margins of Excision
Postoperative Complications
Survival Analysis
Treatment Outcome
Hepatic resection
colorectal liver metastasis
extremely elderly patient
hepatocellular carcinoma
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
03
07
2019
revised:
24
07
2019
accepted:
25
07
2019
entrez:
10
11
2019
pubmed:
11
11
2019
medline:
15
11
2019
Statut:
ppublish
Résumé
We aimed to assess surgical outcome and long-term survival after elective hepatic resection for hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM) in patients aged 80 years or older. This study included 100 patients aged 70 years or older, who underwent hepatic resection for HCC or CRLM between January 2000 and December 2012. Outcomes and clinicopathological data were compared between the elderly (aged 70-79 years; n=84) and extremely elderly groups (aged 80 years or older; n=16). Incidence of postoperative complications, in-hospital mortality, and postoperative OS in the extremely elderly group were comparable with those of the elderly group. In patients with HCC, the extremely elderly group was associated with shorter DFS (p=0.030) in univariate analysis, while multivariate analysis showed significant and independent factors of cancer recurrence. Hepatic resection for HCC and CRLM in patients aged 80 years and older may be safe and acceptable with appropriate selection. For HCC in patients aged 80 years and older, hepatic resection may be effective when negative surgical margins can be achieved.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
We aimed to assess surgical outcome and long-term survival after elective hepatic resection for hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM) in patients aged 80 years or older.
PATIENTS AND METHODS
METHODS
This study included 100 patients aged 70 years or older, who underwent hepatic resection for HCC or CRLM between January 2000 and December 2012. Outcomes and clinicopathological data were compared between the elderly (aged 70-79 years; n=84) and extremely elderly groups (aged 80 years or older; n=16).
RESULTS
RESULTS
Incidence of postoperative complications, in-hospital mortality, and postoperative OS in the extremely elderly group were comparable with those of the elderly group. In patients with HCC, the extremely elderly group was associated with shorter DFS (p=0.030) in univariate analysis, while multivariate analysis showed significant and independent factors of cancer recurrence.
CONCLUSION
CONCLUSIONS
Hepatic resection for HCC and CRLM in patients aged 80 years and older may be safe and acceptable with appropriate selection. For HCC in patients aged 80 years and older, hepatic resection may be effective when negative surgical margins can be achieved.
Identifiants
pubmed: 31704863
pii: 39/11/6325
doi: 10.21873/anticanres.13843
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6325-6332Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.