Co-inheritance of alpha globin gene deletion lowering serum iron level in female beta thalassemia patients.
-α3.7 deletion
Alpha globin gene
Saudi Arabia, iron load
Thalassemia
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
22
03
2019
accepted:
30
10
2019
pubmed:
11
11
2019
medline:
13
6
2020
entrez:
10
11
2019
Statut:
ppublish
Résumé
In the Eastern province of Saudi Arabia, thalassemia is highly common. Data on the effect of alpha globin gene variation on the concentration of iron on transfusion dependent Saudis are scanty. A total of 166 transfusions dependent β-thalassemia were included in this study to understand association between the alpha globin gene variation and concentration of iron. Using multiplex PCR, the alpha globin gene deletions were identified. Also, HBA1 and HBA2 genes were sequenced by Sanger sequencing. Saudi transfusion dependent female β-thalassemia patients with wild alpha globin genotype (αα/αα) were observed with iron level beyond the normal range. However, normal range of iron was observed in transfusion dependent Saudi female beta thalassemia patients co-inherited with double (-α
Identifiants
pubmed: 31705350
doi: 10.1007/s11033-019-05168-w
pii: 10.1007/s11033-019-05168-w
doi:
Substances chimiques
alpha-Globins
0
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
603-606Subventions
Organisme : The Deanship of Scientific Research, Imam Abdulrahman Bin Faisal University
ID : 2012186
Organisme : The Deanship of Scientific Research, Imam Abdulrahman Bin Faisal University
ID : 2014024
Organisme : The Deanship of Scientific Research, Imam Abdulrahman Bin Faisal University
ID : 2016-077-IRMC
Organisme : The Deanship of Scientific Research, Imam Abdulrahman Bin Faisal University
ID : 2014051
Organisme : King Abdulaziz City for Science and Technology
ID : LGP-35-204
Organisme : King Abdulaziz City for Science and Technology
ID : LGP-32-3
Organisme : National Plan for Science, Technology and Innovation
ID : 12-MED 2798-46
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