The role of long non-coding RNAs in the pathogenesis of thyroid cancer.
Expression
Long non-coding RNA
Thyroid cancer
lncRNA
Journal
Experimental and molecular pathology
ISSN: 1096-0945
Titre abrégé: Exp Mol Pathol
Pays: Netherlands
ID NLM: 0370711
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
17
10
2019
revised:
29
10
2019
accepted:
06
11
2019
pubmed:
11
11
2019
medline:
16
7
2020
entrez:
11
11
2019
Statut:
ppublish
Résumé
Long noncoding RNAs (lncRNAs) as prominent regulators of gene expression are involved in different layers of expression regulation. These transcripts participate in carcinogenesis of several human malignancies including thyroid cancer. Availability of high throughput techniques such as RNA sequencing and microarray has facilitated identification of lncRNAs whose dysregulation affect tumorigenesis process. Moreover, assessment of differentially expressed lncRNAs between resistant and sensitive cells has led to recognition of biomarkers for therapeutic response. One elucidated aspect of lncRNAs functions is their role in sponging miRNAs. Several miRNA-lncRNA-mRNA triplets have been recognized till now. Any of these triplets is a putative target of interfering with the evolution of cancer. In the current study, we have summarized recent data in the fields of biology of lncRNAs, their role in thyroid cancer and their potential as biomarker or treatment target.
Identifiants
pubmed: 31706987
pii: S0014-4800(19)30791-9
doi: 10.1016/j.yexmp.2019.104332
pii:
doi:
Substances chimiques
MicroRNAs
0
RNA, Long Noncoding
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104332Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.