A simulation study of gold nanoparticles localisation effects on radiation enhancement at the mitochondrion scale.

Dose-Response Relationship, Drug Gold / chemistry Metal Nanoparticles Mitochondria / drug effects Models, Biological Phantoms, Imaging Radiation-Sensitizing Agents / chemistry
GEANT4 toolkit GNP Mitochondria network

Journal

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
ISSN: 1724-191X
Titre abrégé: Phys Med
Pays: Italy
ID NLM: 9302888

Informations de publication

Date de publication:
Nov 2019
Historique:
received: 30 07 2019
revised: 19 10 2019
accepted: 24 10 2019
pubmed: 11 11 2019
medline: 6 5 2020
entrez: 11 11 2019
Statut: ppublish

Résumé

This paper presents a Monte-Carlo study focusing on the effects of gold nanoparticles on the energy deposition patterns produced by incident photons in the close vicinity of the mitochondrial network modeled as a tube. Spherical shaped gold nanoparticles of 30 nm diameter were placed in a micrometric (10 × 10 × 10 μm

Identifiants

DOI: 10.1016/j.ejmp.2019.10.038 PMID: 31707141
pubmed: 31707141
pii: S1120-1797(19)30488-0
doi: 10.1016/j.ejmp.2019.10.038
pii:
doi:

Substances chimiques

Radiation-Sensitizing Agents 0
Gold 7440-57-5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

148-154

Informations de copyright

Copyright © 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Auteurs

Z Francis (Z)

Saint Joseph University, Faculty of Sciences, Department of Physics, Beirut, Lebanon. Electronic address: ziad.francis@usj.edu.lb.

G Montarou (G)

Clermont Auvergne University, CNRS/IN2P3, Laboratoire de Physique de Clermont, F-63000 Clermont-Ferrand, France.

S Incerti (S)

Centre d'Etudes Nucléaires de Bordeaux Gradignan, Université de Bordeaux 1, CNRS/IN2P3, CENBG, 33175 Gradignan, France.

M Bernal (M)

Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas, SP, Brazil.

S A Zein (SA)

Weill Cornell Medical College, Department of Radiology, New York, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › A simulation study of gold nanoparticles...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Or › A simulation study of gold nanoparticles...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticules métalliques › A simulation study of gold nanoparticles...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › A simulation study of gold nanoparticles...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › A simulation study of gold nanoparticles...
questionsmedicales.fr › Équipement et fournitures › Fantômes en imagerie › A simulation study of gold nanoparticles...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › A simulation study of gold nanoparticles...