Filifactor alocis brain abscess identified by 16S ribosomal RNA gene sequencing: A case report.
16S ribosomal RNA gene sequencing
Brain abscess
Filifactor alocis
Journal
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
ISSN: 1437-7780
Titre abrégé: J Infect Chemother
Pays: Netherlands
ID NLM: 9608375
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
19
06
2019
revised:
16
08
2019
accepted:
24
09
2019
pubmed:
13
11
2019
medline:
12
9
2020
entrez:
13
11
2019
Statut:
ppublish
Résumé
We report a clinical case of Filifactor alocis brain abscess in an 85-year-old man who had decayed teeth 1 week prior. In this case, the abscess was surgically drained after empirical antibiotics had been initiated. Although the causative organism could not be identified by culture, F. alocis was detected via 16S ribosomal RNA (16S rRNA) gene sequencing of the pus isolated from the abscess. The patient recovered without serious sequelae after surgical drainage and prolonged antibiotic treatment, including metronidazole, ceftriaxone and meropenem for 8 weeks. The findings in this case emphasize that 16S rRNA gene sequencing allows bacterial diagnosis of brain abscess when phenotypic identification fails, such as in cases where patients are undergoing antimicrobial treatment at the time of sampling or where patients are infected with fastidious organisms.
Identifiants
pubmed: 31711830
pii: S1341-321X(19)30292-2
doi: 10.1016/j.jiac.2019.09.013
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
RNA, Bacterial
0
RNA, Ribosomal, 16S
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
305-307Informations de copyright
Copyright © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.