A large-scale genomic investigation of susceptibility to infection and its association with mental disorders in the Danish population.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
11 11 2019
11 11 2019
Historique:
received:
05
08
2019
accepted:
03
10
2019
revised:
06
09
2019
entrez:
13
11
2019
pubmed:
13
11
2019
medline:
6
8
2020
Statut:
epublish
Résumé
Infections and mental disorders are two of the major global disease burdens. While correlations between mental disorders and infections have been reported, the possible genetic links between them have not been assessed in large-scale studies. Moreover, the genetic basis of susceptibility to infection is largely unknown, as large-scale genome-wide association studies of susceptibility to infection have been lacking. We utilized a large Danish population-based sample (N = 65,534) linked to nationwide population-based registers to investigate the genetic architecture of susceptibility to infection (heritability estimation, polygenic risk analysis, and a genome-wide association study (GWAS)) and examined its association with mental disorders (comorbidity analysis and genetic correlation). We found strong links between having at least one psychiatric diagnosis and the occurrence of infection (P = 2.16 × 10
Identifiants
pubmed: 31712607
doi: 10.1038/s41398-019-0622-3
pii: 10.1038/s41398-019-0622-3
pmc: PMC6848113
doi:
Substances chimiques
Genetic Markers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
283Subventions
Organisme : NIMH NIH HHS
ID : U01 MH094432
Pays : United States
Références
Am J Hum Genet. 2011 Mar 11;88(3):294-305
pubmed: 21376301
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Cell. 2018 Jun 14;173(7):1573-1580
pubmed: 29906445
Dan Med Bull. 1999 Jun;46(3):263-8
pubmed: 10421985
Nat Neurosci. 2019 Mar;22(3):353-361
pubmed: 30692689
Nat Genet. 2016 Jul;48(7):817-20
pubmed: 27270105
Am J Hum Genet. 2011 Jan 7;88(1):76-82
pubmed: 21167468
Fly (Austin). 2012 Apr-Jun;6(2):80-92
pubmed: 22728672
Nucleic Acids Res. 2017 Jan 4;45(D1):D896-D901
pubmed: 27899670
Scand J Public Health. 2011 Jul;39(7 Suppl):54-7
pubmed: 21775352
Mol Psychiatry. 2018 Jan;23(1):6-14
pubmed: 28924187
Diabetologia. 2007 Mar;50(3):549-54
pubmed: 17187246
J Autoimmun. 2016 Nov;74:176-181
pubmed: 27267460
Nat Immunol. 2010 Jul;11(7):628-34
pubmed: 20526343
J Inherit Metab Dis. 2007 Aug;30(4):530-6
pubmed: 17632694
Nat Rev Genet. 2010 May;11(5):356-66
pubmed: 20395969
PLoS One. 2015 May 13;10(5):e0124005
pubmed: 25970427
Am J Med Genet B Neuropsychiatr Genet. 2018 Oct;177(7):641-657
pubmed: 30325587
Bioinformatics. 2015 May 1;31(9):1466-8
pubmed: 25550326
Brain Behav Immun. 2021 Jan;91:10-23
pubmed: 32534018
Nat Commun. 2017 Sep 19;8(1):599
pubmed: 28928442
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Neuron. 1999 Aug;23(4):703-11
pubmed: 10482237
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Nat Genet. 2015 Nov;47(11):1236-41
pubmed: 26414676
J Infect Dis. 2008 Jan 1;197(1):18-24
pubmed: 18171280
Semin Immunol. 1998 Feb;10(1):5-13
pubmed: 9529651
Nature. 2001 Apr 19;410(6831):948-52
pubmed: 11309622
N Engl J Med. 1988 Mar 24;318(12):727-32
pubmed: 3347221
PLoS Genet. 2009 Jun;5(6):e1000529
pubmed: 19543373
Carcinogenesis. 2010 Jan;31(1):37-49
pubmed: 19955394
PLoS One. 2015 Mar 17;10(3):e0116696
pubmed: 25781172
Dan Med J. 2013 Feb;60(2):A4578
pubmed: 23461991
Genes Immun. 2012 Feb;13(2):184-90
pubmed: 21993531
JAMA Psychiatry. 2013 Aug;70(8):812-20
pubmed: 23760347
Eur J Hum Genet. 2019 Sep;27(9):1445-1455
pubmed: 30976114
Am J Psychiatry. 2011 Dec;168(12):1303-10
pubmed: 22193673
Scand J Public Health. 2011 Jul;39(7 Suppl):22-5
pubmed: 21775345
Biol Psychiatry. 2016 Oct 15;80(8):609-16
pubmed: 27364036
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Sci Rep. 2015 Nov 03;5:16119
pubmed: 26524966
Nat Rev Genet. 2012 Feb 07;13(3):175-88
pubmed: 22310894
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:133-147
pubmed: 30610941
Hum Genet. 2017 Jan;136(1):75-83
pubmed: 27752767