Metabolic Dysfunction in Continuous-Flow Left Ventricular Assist Devices Patients and Outcomes.
Aged
Comorbidity
Diabetes Mellitus
/ epidemiology
Endocrine System Diseases
/ epidemiology
Euthyroid Sick Syndromes
/ epidemiology
Female
Glycated Hemoglobin
/ metabolism
Heart Failure
/ epidemiology
Heart-Assist Devices
Hospitalization
/ statistics & numerical data
Humans
Hyperthyroidism
/ epidemiology
Hypothyroidism
/ epidemiology
Insulin Resistance
Male
Metabolic Diseases
/ epidemiology
Middle Aged
Prognosis
Testosterone
/ deficiency
Thyroid Diseases
/ epidemiology
Thyrotropin
/ metabolism
Thyroxine
/ metabolism
Treatment Outcome
diabetes mellitus
heart failure
left ventricular assist device
testosterone
thyroid hormones
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
19 11 2019
19 11 2019
Historique:
entrez:
14
11
2019
pubmed:
14
11
2019
medline:
15
12
2020
Statut:
ppublish
Résumé
Background Metabolic impairment is common in heart failure patients. Continuous-flow left ventricular assist devices (CF-LVADs) improve hemodynamics and outcomes in patients with advanced heart failure; however, the effect of CF-LVADs on metabolic status is unknown. This study aims to evaluate the changes in metabolic status following CF-LVAD implantation and measure the correlation of metabolic status with outcomes. Methods and Results Prospective data on CF-LVAD patients were obtained. Metabolic evaluation, including hemoglobin A1C, free and total testosterone, thyroid-stimulating hormone (TSH), and free T4, was obtained before and at multiple time points following implantation. Patients with nonelevated thyroid-stimulating hormone and normal hemoglobin A1C and testosterone levels were defined as having normal metabolic status. Baseline characteristics, hemodynamics, and outcomes were collected. One hundred six patients were studied, of which 56 had paired data at baseline and 1- to 3-month follow-up. Before implantation, 75% of patients had insulin resistance, 86% of men and 39% of women had low free testosterone, and 44% of patients had abnormal thyroid function. There was a significant improvement in hemoglobin A1C, free testosterone, and thyroid-stimulating hormone following implantation (
Identifiants
pubmed: 31718441
doi: 10.1161/JAHA.119.013278
pmc: PMC6915293
doi:
Substances chimiques
Glycated Hemoglobin A
0
hemoglobin A1c protein, human
0
Testosterone
3XMK78S47O
Thyrotropin
9002-71-5
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e013278Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL007381
Pays : United States
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