Epidermal growth factor receptor signaling suppresses αvβ6 integrin and promotes periodontal inflammation and bone loss.
Alveolar Bone Loss
/ pathology
Animals
Antigens, Neoplasm
/ genetics
Biofilms
Cells, Cultured
Epithelial Cells
/ metabolism
ErbB Receptors
/ metabolism
Gingiva
/ cytology
Humans
Inflammation Mediators
/ metabolism
Integrins
/ genetics
Mice
Periodontal Diseases
/ genetics
Phosphorylation
Signal Transduction
Transforming Growth Factor beta1
/ metabolism
Biofilm
Epidermal growth factor receptor
Inflammation
Periodontal disease
αvβ6 integrin
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
05 12 2019
05 12 2019
Historique:
received:
15
07
2019
accepted:
05
11
2019
pubmed:
15
11
2019
medline:
22
9
2020
entrez:
15
11
2019
Statut:
epublish
Résumé
In periodontal disease (PD), bacterial biofilms cause gingival inflammation, leading to bone loss. In healthy individuals, αvβ6 integrin in junctional epithelium maintains anti-inflammatory transforming growth factor-β1 (TGF-β1) signaling, whereas its expression is lost in individuals with PD. Bacterial biofilms suppress β6 integrin expression in cultured gingival epithelial cells (GECs) by attenuating TGF-β1 signaling, leading to an enhanced pro-inflammatory response. In the present study, we show that GEC exposure to biofilms induced activation of mitogen-activated protein kinases and epidermal growth factor receptor (EGFR). Inhibition of EGFR and ERK stunted both the biofilm-induced
Identifiants
pubmed: 31722981
pii: jcs.236588
doi: 10.1242/jcs.236588
pii:
doi:
Substances chimiques
Antigens, Neoplasm
0
Inflammation Mediators
0
Integrins
0
Transforming Growth Factor beta1
0
integrin alphavbeta6
0
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : PJT-153379
Pays : Canada
Organisme : CIHR
ID : PJT-156387
Pays : Canada
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.