The loss of NMDAR-dependent LTD following cannabinoid self-administration is restored by positive allosteric modulation of CB1 receptors.
Allosteric Regulation
/ drug effects
Animals
Behavior, Addictive
/ chemically induced
Cannabidiol
/ administration & dosage
Cannabinoid Receptor Agonists
/ administration & dosage
Cannabinoids
/ administration & dosage
Dronabinol
/ administration & dosage
Glutamic Acid
/ metabolism
Indoles
/ administration & dosage
Long-Term Synaptic Depression
/ drug effects
Male
Nucleus Accumbens
/ drug effects
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1
/ agonists
Receptors, N-Methyl-D-Aspartate
/ physiology
Self Administration
Synaptic Transmission
/ drug effects
addiction
cannabinoids
synaptic plasticity
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
14
01
2019
revised:
28
09
2019
accepted:
30
09
2019
pubmed:
17
11
2019
medline:
29
9
2021
entrez:
17
11
2019
Statut:
ppublish
Résumé
Glutamatergic plasticity in the nucleus accumbens core (NAcore) is a key neuronal process in appetitive learning and contributes to pathologies such as drug addiction. Understanding how this plasticity factors into cannabis addiction and relapse has been hampered by the lack of a rodent model of cannabis self-administration. We used intravenous self-administration of two constituents of cannabis, Δ
Identifiants
pubmed: 31733097
doi: 10.1111/adb.12843
pmc: PMC7962172
mid: NIHMS1674029
doi:
Substances chimiques
3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole
0
Cannabinoid Receptor Agonists
0
Cannabinoids
0
Indoles
0
Receptor, Cannabinoid, CB1
0
Receptors, N-Methyl-D-Aspartate
0
Cannabidiol
19GBJ60SN5
Glutamic Acid
3KX376GY7L
Dronabinol
7J8897W37S
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12843Subventions
Organisme : NIGMS NIH HHS
ID : R25 GM113278
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA003906
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM072643
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA016511
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA012513
Pays : United States
Organisme : BLRD VA
ID : I01 BX004727
Pays : United States
Organisme : NIH HHS
ID : GM072643
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA015369
Pays : United States
Organisme : NIH HHS
ID : DA015369
Pays : United States
Organisme : NIDA NIH HHS
ID : R37 DA003906
Pays : United States
Informations de copyright
© 2019 Society for the Study of Addiction.
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