Differential properties of mitosis-associated events following CHK1 and WEE1 inhibitor treatments in human tongue carcinoma cells.
Cdh1 Proteins
/ genetics
Cell Cycle Proteins
/ antagonists & inhibitors
Cell Line, Tumor
Checkpoint Kinase 1
/ antagonists & inhibitors
DNA Damage
Epithelial Cells
/ drug effects
Flow Cytometry
G2 Phase Cell Cycle Checkpoints
/ drug effects
Gene Expression Regulation, Neoplastic
Genes, Reporter
HeLa Cells
Histones
/ genetics
Humans
Mitosis
/ drug effects
Protein Kinase Inhibitors
/ pharmacology
Protein Serine-Threonine Kinases
/ antagonists & inhibitors
Protein-Tyrosine Kinases
/ antagonists & inhibitors
S Phase
/ drug effects
S-Phase Kinase-Associated Proteins
/ genetics
Signal Transduction
Time-Lapse Imaging
CHK1
Endomitosis
Fluorescent ubiquitination-based cell cycle indicator (Fucci)
Spindle checkpoint
WEE1
Journal
Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226
Informations de publication
Date de publication:
15 01 2020
15 01 2020
Historique:
received:
28
09
2019
revised:
08
11
2019
accepted:
10
11
2019
pubmed:
19
11
2019
medline:
17
7
2020
entrez:
19
11
2019
Statut:
ppublish
Résumé
CHK1 and WEE1 play pivotal roles in G2/M checkpoint following exogenous DNA damage and regulation of DNA replication under normal cellular conditions. Here, we monitored and compared the cell cycle kinetics of mitosis-associated events after CHK1 and WEE1 inhibitor treatments in a human tongue cancer cell line (SAS). A fluorescent ubiquitination-based cell cycle indicator (Fucci) that reflects SCF
Identifiants
pubmed: 31738907
pii: S0014-4827(19)30599-3
doi: 10.1016/j.yexcr.2019.111720
pii:
doi:
Substances chimiques
Cdh1 Proteins
0
Cell Cycle Proteins
0
H2AX protein, human
0
Histones
0
Protein Kinase Inhibitors
0
S-Phase Kinase-Associated Proteins
0
Protein-Tyrosine Kinases
EC 2.7.10.1
WEE1 protein, human
EC 2.7.10.2
CHEK1 protein, human
EC 2.7.11.1
Checkpoint Kinase 1
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
TTK protein, human
EC 2.7.12.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111720Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.