SERS determination of the antihypertensive drugs prazosin and losartan by using silver nanoparticles coated with β-cyclodextrin.
DFT calculations
Healthcare products
Losartan potassium
Prazosin hydrochloride
Surface-enhanced Raman scattering
β-Cyclodextrin
Journal
Mikrochimica acta
ISSN: 1436-5073
Titre abrégé: Mikrochim Acta
Pays: Austria
ID NLM: 7808782
Informations de publication
Date de publication:
18 11 2019
18 11 2019
Historique:
received:
13
06
2019
accepted:
14
10
2019
entrez:
20
11
2019
pubmed:
20
11
2019
medline:
14
5
2020
Statut:
epublish
Résumé
A surface-enhanced Raman scattering (SERS) method is described for the determination of prazosin (PRH) and losartan (LOS). Silver nanoparticles modified with β-cyclodextrin (CD-S-Ag NPs) were prepared and serve as a sensitive SERS substrate. β-CD is both a reductant for silver ions and a host molecule that binds the analytes which leads to strong SERS enhancement. The method has distinct features: (a) The linear response extends from 0.1 to 60 μM for PRH, and from 1.0 to 100 μM for LOS; (b) the respective limits of detection are as low as 15 nM and 0.92 μM; and (c) the specific SERS bands of PRH and LOS are located at 703 and 1298 cm
Identifiants
pubmed: 31741056
doi: 10.1007/s00604-019-3946-z
pii: 10.1007/s00604-019-3946-z
doi:
Substances chimiques
Antihypertensive Agents
0
beta-Cyclodextrins
0
Silver
3M4G523W1G
Losartan
JMS50MPO89
betadex
JV039JZZ3A
Prazosin
XM03YJ541D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
801Subventions
Organisme : Science-Technology Development Project of Jilin Province of China
ID : 20170101174JC
Pays : International
Organisme : National Natural Science Foundation of China
ID : 21327803
Pays : International
Organisme : National Natural Science Foundation of China
ID : 21773080
Pays : International
Organisme : National Natural Science Foundation of China
ID : 21711540292
Pays : International
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