Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis.
NCAM
chondrocyte differentiation
chondrocyte hypertrophy
mesenchymal stem cells
osteoarthritis
Journal
Stem cells translational medicine
ISSN: 2157-6580
Titre abrégé: Stem Cells Transl Med
Pays: England
ID NLM: 101578022
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
01
07
2019
accepted:
25
10
2019
pubmed:
20
11
2019
medline:
22
7
2021
entrez:
20
11
2019
Statut:
ppublish
Résumé
Chondrocyte hypertrophy-like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of mesenchymal stem cells (MSCs). In this study, we found that NCAM deficiency accelerates chondrocyte hypertrophy in articular cartilage and growth plate of OA mice. NCAM deficiency leads to hypertrophic chondrocyte differentiation in both murine MSCs and chondrogenic cells, in which extracellular signal-regulated kinase (ERK) signaling plays an important role. Moreover, NCAM expression is downregulated in an interleukin-1β-stimulated OA cellular model and monosodium iodoacetate-induced OA rats. Overexpression of NCAM substantially inhibits hypertrophic differentiation in the OA cellular model. In conclusion, NCAM could inhibit hypertrophic chondrocyte differentiation of MSCs by inhibiting ERK signaling and reduce chondrocyte hypertrophy in experimental OA model, suggesting the potential utility of NCAM as a novel therapeutic target for alleviating chondrocyte hypertrophy of OA.
Identifiants
pubmed: 31742919
doi: 10.1002/sctm.19-0190
pmc: PMC6988767
doi:
Substances chimiques
Neural Cell Adhesion Molecules
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
273-283Informations de copyright
© 2019 The Authors. Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.
Références
Exp Cell Res. 1994 Dec;215(2):354-62
pubmed: 7982473
J Cell Sci. 2011 Aug 1;124(Pt 15):2552-60
pubmed: 21730021
Int J Dev Biol. 1999 Jul;43(4):335-42
pubmed: 10470650
Exp Neurol. 2006 Mar;198(1):54-64
pubmed: 16336965
Inflamm Res. 2016 Jun;65(6):439-48
pubmed: 26892680
Arthritis Rheum. 2008 May;58(5):1377-88
pubmed: 18438858
Exp Gerontol. 1998 Nov-Dec;33(7-8):853-64
pubmed: 9951628
Osteoarthritis Cartilage. 2012 Mar;20(3):223-32
pubmed: 22178514
J Cell Biochem. 1999 Mar 15;72(4):549-57
pubmed: 10022614
Exp Cell Res. 2012 Oct 15;318(17):2257-67
pubmed: 22683856
Nat Rev Rheumatol. 2011 Jan;7(1):33-42
pubmed: 21119608
Biorheology. 2004;41(3-4):535-42
pubmed: 15299284
Dev Biol. 2003 Nov 15;263(2):165-75
pubmed: 14597193
J Am Acad Orthop Surg. 2014 Jul;22(7):467-8
pubmed: 24966254
Mol Cell Biol. 2008 Jan;28(1):344-57
pubmed: 17967876
Arthritis Res Ther. 2010;12(5):216
pubmed: 20959023
Ann N Y Acad Sci. 2009 Sep;1176:124-34
pubmed: 19796240
J Cell Biochem. 2010 Jun 1;110(3):573-80
pubmed: 20512918
Maturitas. 2014 Jul;78(3):188-98
pubmed: 24855933
Anat Embryol (Berl). 1997 Nov;196(5):349-62
pubmed: 9406838
BMC Public Health. 2016 Jan 30;16:94
pubmed: 26830813
Int J Mol Sci. 2014 Nov 17;15(11):21270-85
pubmed: 25407530
J Cell Biochem. 2006 Jan 1;97(1):33-44
pubmed: 16215986
J Biol Chem. 2012 Apr 27;287(18):14803-15
pubmed: 22399299
Development. 2015 Mar 1;142(5):817-31
pubmed: 25715393
Bone. 2001 May;28(5):491-8
pubmed: 11344048
J Cell Biol. 2003 Sep 1;162(5):833-42
pubmed: 12952936
Mediators Inflamm. 2014;2014:561459
pubmed: 24876674
J Cell Physiol. 2007 Oct;213(1):1-8
pubmed: 17492773
Lancet. 2012 Dec 15;380(9859):2197-223
pubmed: 23245608
Nat Rev Rheumatol. 2013 Oct;9(10):584-94
pubmed: 23881068
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4397-402
pubmed: 11917104
J Bone Miner Res. 2005 May;20(5):867-77
pubmed: 15824860
J Cell Physiol. 1993 Aug;156(2):399-411
pubmed: 8344994
Int J Dev Neurosci. 2000 Apr-Jun;18(2-3):193-9
pubmed: 10715574
Annu Rev Biochem. 1997;66:823-62
pubmed: 9242926
J Mol Med (Berl). 2013 Mar;91(3):369-80
pubmed: 22965193
J Cell Physiol. 2005 Jan;202(1):1-8
pubmed: 15389526
Arthritis Rheum. 2012 Oct;64(10):3355-63
pubmed: 22674197
Int J Dev Biol. 1995 Jun;39(3):519-28
pubmed: 7577443
Cloning Stem Cells. 2009 Mar;11(1):61-76
pubmed: 19196040
Stem Cells Transl Med. 2020 Feb;9(2):273-283
pubmed: 31742919
Eur Cell Mater. 2012 Jul 24;24:118-35; discussion 135
pubmed: 22828990
Histol Histopathol. 2014 Jun;29(6):669-89
pubmed: 24452855
Ann Rheum Dis. 2014 Aug;73(8):1442-5
pubmed: 24625626
J Biol Chem. 2005 Dec 30;280(52):42971-7
pubmed: 16267048
Genes Dev. 2004 Apr 15;18(8):952-63
pubmed: 15107406
Endocrinology. 2009 Jul;150(7):3067-75
pubmed: 19213846