Cognitive performance and cognitive workload in multiple sclerosis: Two different constructs of cognitive functioning?
Cognition
Cognitive workload
Multiple sclerosis
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
03
07
2019
revised:
24
09
2019
accepted:
04
11
2019
pubmed:
20
11
2019
medline:
20
1
2021
entrez:
20
11
2019
Statut:
ppublish
Résumé
Cognitive impairment in individuals with Multiple Sclerosis (iwMS) is traditionally diagnosed using performance measures on cognitive tests. Yet, performance on cognitive tests does not convey the amount of mental effort or cognitive workload it takes to complete the task. The main aim was to evaluate whether cognitive performance and cognitive workload are two different constructs of cognitive functioning in iwMS. IwMS were categorized into cognitive impairments (iwMS+, n = 10) and no cognitive impairments (iwMS-, n = 12) using their performance on Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Their scores on BICAMS, Stroop, and trail making tests were compared to age- and education-matched controls (n = 22). Cognitive workload was assessed using the self-reported NASA Task Load Index and the Index of Cognitive Activity, derived from pupillary response. IwMS+ performed worse on most cognitive tests compared to iwMS- and controls. However, iwMS+ did not report or exhibit greater cognitive workload compared to the other groups. Potential confounding variables, such as sex, use of antidepressants, and symptoms of depression, fatigue, and dysautonomia did not influence the lack of correlation between cognitive performance and cognitive workload in all three groups. Cognitive performance and cognitive workload seem to measure different cognitive constructs of cognitive functioning in MS. Our results suggest that iwMS+ do not show effective allocation of cognitive resources to compensate for deteriorated performance in cognitive tests.
Sections du résumé
BACKGROUND
BACKGROUND
Cognitive impairment in individuals with Multiple Sclerosis (iwMS) is traditionally diagnosed using performance measures on cognitive tests. Yet, performance on cognitive tests does not convey the amount of mental effort or cognitive workload it takes to complete the task. The main aim was to evaluate whether cognitive performance and cognitive workload are two different constructs of cognitive functioning in iwMS.
METHODS
METHODS
IwMS were categorized into cognitive impairments (iwMS+, n = 10) and no cognitive impairments (iwMS-, n = 12) using their performance on Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Their scores on BICAMS, Stroop, and trail making tests were compared to age- and education-matched controls (n = 22). Cognitive workload was assessed using the self-reported NASA Task Load Index and the Index of Cognitive Activity, derived from pupillary response.
RESULTS
RESULTS
IwMS+ performed worse on most cognitive tests compared to iwMS- and controls. However, iwMS+ did not report or exhibit greater cognitive workload compared to the other groups. Potential confounding variables, such as sex, use of antidepressants, and symptoms of depression, fatigue, and dysautonomia did not influence the lack of correlation between cognitive performance and cognitive workload in all three groups.
CONCLUSION
CONCLUSIONS
Cognitive performance and cognitive workload seem to measure different cognitive constructs of cognitive functioning in MS. Our results suggest that iwMS+ do not show effective allocation of cognitive resources to compensate for deteriorated performance in cognitive tests.
Identifiants
pubmed: 31743847
pii: S2211-0348(19)30494-8
doi: 10.1016/j.msard.2019.101505
pii:
doi:
Substances chimiques
Sevelamer
9YCX42I8IU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101505Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors report no conflict of interest.