Genetic dynamics in untreated CLL patients with either stable or progressive disease: a longitudinal study.
Chronic lymphocytic leukemia
Clonal evolution
Copy number variation
Nucleotide variation
Journal
Journal of hematology & oncology
ISSN: 1756-8722
Titre abrégé: J Hematol Oncol
Pays: England
ID NLM: 101468937
Informations de publication
Date de publication:
19 11 2019
19 11 2019
Historique:
received:
02
08
2019
accepted:
09
10
2019
entrez:
21
11
2019
pubmed:
21
11
2019
medline:
7
7
2020
Statut:
epublish
Résumé
Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive disease shift. We found that clonal evolution occurs in all CLL patients, irrespective of the clinical outcome, but is faster during disease progression. In particular, changes in the frequency of nucleotide variants (NVs) in specific CLL-related genes may represent an indicator of poor clinical outcome.
Identifiants
pubmed: 31744508
doi: 10.1186/s13045-019-0802-x
pii: 10.1186/s13045-019-0802-x
pmc: PMC6862808
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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