Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity.
IL-15
differentiation
education
homeostasis
killer cell immunoglobulin-like receptors
natural killer cells
plasticity
single-cell RNA sequencing
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
19 Nov 2019
19 Nov 2019
Historique:
received:
20
02
2019
revised:
28
08
2019
accepted:
14
10
2019
entrez:
21
11
2019
pubmed:
21
11
2019
medline:
22
9
2020
Statut:
ppublish
Résumé
Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive. Here, we show that subset-specific NK cell proliferation kinetics correlate with mTOR activation, and global repertoire diversity is maintained through a high degree of intra-lineage subset plasticity during interleukin (IL)-15-driven homeostatic proliferation in vitro. Slowly cycling sorted KIR
Identifiants
pubmed: 31747601
pii: S2211-1247(19)31372-5
doi: 10.1016/j.celrep.2019.10.058
pii:
doi:
Substances chimiques
CD56 Antigen
0
CD57 Antigens
0
IL15 protein, human
0
Interleukin-15
0
KLRC1 protein, human
0
NF-kappa B
0
NK Cell Lectin-Like Receptor Subfamily C
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2284-2294.e4Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.