Action perception recruits the cerebellum and is impaired in patients with spinocerebellar ataxia.
cerebellar function
imaging methodology
movement disorders
social cognition
spincocerebellar ataxia
Journal
Brain : a journal of neurology
ISSN: 1460-2156
Titre abrégé: Brain
Pays: England
ID NLM: 0372537
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
received:
19
11
2018
revised:
02
09
2019
accepted:
09
09
2019
pubmed:
21
11
2019
medline:
22
5
2020
entrez:
21
11
2019
Statut:
ppublish
Résumé
Our cerebellum has been proposed to generate prediction signals that may help us plan and execute our motor programmes. However, to what extent our cerebellum is also actively involved in perceiving the action of others remains to be elucidated. Using functional MRI, we show here that observing goal-directed hand actions of others bilaterally recruits lobules VI, VIIb and VIIIa in the cerebellar hemispheres. Moreover, whereas healthy subjects (n = 31) were found to be able to discriminate subtle differences in the kinematics of observed limb movements of others, patients suffering from spinocerebellar ataxia type 6 (SCA6; n = 21) were severely impaired in performing such tasks. Our data suggest that the human cerebellum is actively involved in perceiving the kinematics of the hand actions of others and that SCA6 patients' deficits include a difficulty in perceiving the actions of other individuals. This finding alerts us to the fact that cerebellar disorders can alter social cognition.
Identifiants
pubmed: 31747689
pii: 5628037
doi: 10.1093/brain/awz337
pmc: PMC7409410
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3791-3805Informations de copyright
© The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain.
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