Impact of sleep opportunity on asthma outcomes in adolescents.
Adolescence
Pediatrics
Quality of life
Sleep extension
Sleep restriction
Journal
Sleep medicine
ISSN: 1878-5506
Titre abrégé: Sleep Med
Pays: Netherlands
ID NLM: 100898759
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
01
03
2019
revised:
11
07
2019
accepted:
13
07
2019
pubmed:
22
11
2019
medline:
27
10
2020
entrez:
22
11
2019
Statut:
ppublish
Résumé
Insufficient sleep is associated with a number of negative health outcomes; as most adolescents obtain <7 h of sleep per night, it is important to understand how sleep impacts asthma among adolescents. To examine the impact of sleep opportunity on asthma in adolescents. In this study, 54 adolescents with asthma (12-17 years, 69% female, 65% Caucasian) participated in a randomized, cross-over sleep manipulation trial, including a sleep stabilization week, five nights of a "Short" sleep opportunity (time in bed: 6.5 h/night), and five nights of a "Long" sleep opportunity (time in bed: 9.5 h/night). Wake times were consistent across all three study weeks. Primary outcomes were lung function (daily peak expiratory flow rate, weekly spirometry) and functional asthma outcomes (daily asthma symptoms, Asthma Control Questionnaire, PROMIS Asthma Impact Scale). Markers of inflammation were also explored. Compared to the Long sleep week, during the Short sleep week, morning FEV1 was lower (p = 0.006), while asthma symptoms and albuterol use was higher (p < 0.05), and asthma showed a trend towards greater negative impact on daily life (p = 0.07). No differences were found for weekly measures of lung function or inflammation. An insufficient sleep opportunity negatively impacts objective and subjective daily symptoms of asthma in adolescents, as well as health related quality of life. As most adolescents are significantly sleep deprived, it is important to target sleep health in the treatment of asthma.
Identifiants
pubmed: 31751908
pii: S1389-9457(19)30251-5
doi: 10.1016/j.sleep.2019.07.014
pmc: PMC9354610
mid: NIHMS1544060
pii:
doi:
Substances chimiques
Albuterol
QF8SVZ843E
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
134-141Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL119441
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025780
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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