Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis.


Journal

Environmental science & technology
ISSN: 1520-5851
Titre abrégé: Environ Sci Technol
Pays: United States
ID NLM: 0213155

Informations de publication

Date de publication:
07 01 2020
Historique:
pubmed: 23 11 2019
medline: 18 6 2020
entrez: 23 11 2019
Statut: ppublish

Résumé

The use of omics is gaining importance in the field of nanoecotoxicology; an increasing number of studies are aiming to investigate the effects and modes of action of engineered nanomaterials (ENMs) in this way. However, a systematic synthesis of the outcome of such studies regarding common responses and toxicity pathways is currently lacking. We developed an R-scripted computational pipeline to perform reanalysis and functional analysis of relevant transcriptomic data sets using a common approach, independent from the ENM type, and across different organisms, including

Identifiants

pubmed: 31752483
doi: 10.1021/acs.est.9b05170
pmc: PMC6950232
doi:

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

335-344

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Auteurs

Michael Burkard (M)

Swiss Federal Institute of Technology, Eawag, 8600 Dübendorf, Switzerland.

Alexander Betz (A)

Swiss Federal Institute of Technology, Eawag, 8600 Dübendorf, Switzerland.

Kristin Schirmer (K)

Swiss Federal Institute of Technology, Eawag, 8600 Dübendorf, Switzerland.
Institute of Biogeochemistry and Pollutant Dynamics, ETH Zürich, 8092 Zürich, Switzerland.
School of Architecture, Civil and Environmental Engineering, EPFL Lausanne, 1015 Lausanne, Switzerland.

Anze Zupanic (A)

Swiss Federal Institute of Technology, Eawag, 8600 Dübendorf, Switzerland.

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Classifications MeSH