Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity.
Animals
Calorimetry
Diet, High-Fat
Enterocytes
/ metabolism
Fatty Acids
/ metabolism
Gene Deletion
Gene Expression Regulation
Histone Deacetylases
/ genetics
Intestinal Mucosa
/ metabolism
Lipid Metabolism
/ genetics
Lipid Peroxidation
/ genetics
Lipidomics
Mice
Mitochondria
/ metabolism
Obesity
/ genetics
Peroxisome Proliferator-Activated Receptors
/ agonists
Triglycerides
/ metabolism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
22 11 2019
22 11 2019
Historique:
received:
15
01
2018
accepted:
23
10
2019
entrez:
24
11
2019
pubmed:
24
11
2019
medline:
3
3
2020
Statut:
epublish
Résumé
Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulating lipid metabolism in the intestinal epithelium is unknown. Here we demonstrate that intestine-specific deletion of Hdac3 (Hdac3
Identifiants
pubmed: 31757939
doi: 10.1038/s41467-019-13180-8
pii: 10.1038/s41467-019-13180-8
pmc: PMC6876593
doi:
Substances chimiques
Fatty Acids
0
Peroxisome Proliferator-Activated Receptors
0
Triglycerides
0
Histone Deacetylases
EC 3.5.1.98
histone deacetylase 3
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5291Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA064140
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA164605
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA178030
Pays : United States
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