Shivakumar Keerthikumar

Affiliations

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.

Publications (12)

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis.

Nature communications

Avec: Monisha Samuel , Pamali Fonseka , Rahul Sanwlani , Lahiru Gangoda , Sing Ho Chee , Shivakumar Keerthikumar , Alex Spurling , Sai V Chitti , Damien Zanker , Ching-Seng Ang , Ishara Atukorala , Taeyoung Kang , Sanjay Shahi , Akbar L Marzan , Christina Nedeva , Claire Vennin , Morghan C Lucas , Lesley Cheng , David Herrmann , Mohashin Pathan , David Chisanga , Sean C Warren , Kening Zhao , Nidhi Abraham , Sushma Anand , Stephanie Boukouris , Christopher G Adda , Lanzhou Jiang , Tanmay M Shekhar , Nikola Baschuk , Christine J Hawkins , Amelia J Johnston , Jacqueline Monique Orian , Nicholas J Hoogenraad , Ivan K Poon , Andrew F Hill , Markandeya Jois , Paul Timpson , Belinda S Parker , Suresh Mathivanan

Analytical validation of an error-corrected ultra-sensitive ctDNA next-generation sequencing assay.

BioTechniques

Avec: Heidi Fettke , Jason A Steen , Edmond M Kwan , Patricia Bukczynska , Shivakumar Keerthikumar , David Goode , Maria Docanto , Nicole Ng , Luciano Martelotto , Christine Hauser , Melissa C Southey , Arun A Azad , Tu Nguyen-Dumont

CRISP3 expression drives prostate cancer invasion and progression.

Endocrine-related cancer

Avec: Marianna Volpert , Luc Furic , Jinghua Hu , Anne E O'Connor , Richard J Rebello , Shivakumar Keerthikumar , Jemma Evans , D Jo Merriner , John Pedersen , Gail P Risbridger , Peter McIntyre , Moira K O'Bryan

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer.

Science (New York, N.Y.)

Avec: Arcadi Cipponi , David L Goode , Justin Bedo , Mark J McCabe , Marina Pajic , David R Croucher , Alvaro Gonzalez Rajal , Simon R Junankar , Darren N Saunders , Pavel Lobachevsky , Anthony T Papenfuss , Danielle Nessem , Max Nobis , Sean C Warren , Paul Timpson , Mark Cowley , Ana C Vargas , Min R Qiu , Daniele G Generali , Shivakumar Keerthikumar , Uyen Nguyen , Niall M Corcoran , Georgina V Long , Jean-Yves Blay , David M Thomas

Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells.

Journal of extracellular vesicles

Avec: Hina Kalra , Lahiru Gangoda , Pamali Fonseka , Sai V Chitti , Michael Liem , Shivakumar Keerthikumar , Monisha Samuel , Stephanie Boukouris , Haidar Al Saffar , Christine Collins , Christopher G Adda , Ching-Seng Ang , Suresh Mathivanan

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology.

Nature communications

Avec: Gail P Risbridger , Ashlee K Clark , Laura H Porter , Roxanne Toivanen , Andrew Bakshi , Natalie L Lister , David Pook , Carmel J Pezaro , Shahneen Sandhu , Shivakumar Keerthikumar , Rosalia Quezada Urban , Melissa Papargiris , Jenna Kraska , Heather B Madsen , Hong Wang , Michelle G Richards , Birunthi Niranjan , Samantha O'Dea , Linda Teng , William Wheelahan , Zhuoer Li , Nicholas Choo , John F Ouyang , Heather Thorne , Lisa Devereux , Rodney J Hicks , Shomik Sengupta , Laurence Harewood , Mahesh Iddawala , Arun A Azad , Jeremy Goad , Jeremy Grummet , John Kourambas , Edmond M Kwan , Daniel Moon , Declan G Murphy , John Pedersen , David Clouston , Sam Norden , Andrew Ryan , Luc Furic , David L Goode , Mark Frydenberg , Mitchell G Lawrence , Renea A Taylor

Low-dose carboplatin modifies the tumor microenvironment to augment CAR T cell efficacy in human prostate cancer models.

Nature communications

Avec: L H Porter , J J Zhu , N L Lister , S G Harrison , S Keerthikumar , D L Goode , R Quezada Urban , D J Byrne , A Azad , I Vela , M S Hofman , P J Neeson , P K Darcy , J A Trapani , R A Taylor , G P Risbridger

Co-targeting BET, CBP, and p300 inhibits neuroendocrine signalling in androgen receptor-null prostate cancer.

The Journal of pathology

Avec: Nicholas Choo , Shivakumar Keerthikumar , Susanne Ramm , Daisaku Ashikari , Linda Teng , Birunthi Niranjan , Shelley Hedwards , Laura H Porter , David L Goode , Kaylene J Simpson , Renea A Taylor , Gail P Risbridger , Mitchell G Lawrence

Extracellular vesicles secreted by

Communications biology

Avec: Kening Zhao , Mark Bleackley , David Chisanga , Lahiru Gangoda , Pamali Fonseka , Michael Liem , Hina Kalra , Haidar Al Saffar , Shivakumar Keerthikumar , Ching-Seng Ang , Christopher G Adda , Lanzhou Jiang , Kuok Yap , Ivan K Poon , Peter Lock , Vincent Bulone , Marilyn Anderson , Suresh Mathivanan

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity.

Nature communications

Avec: Mercedes Dávalos-Salas , Magdalene K Montgomery , Camilla M Reehorst , Rebecca Nightingale , Irvin Ng , Holly Anderton , Sheren Al-Obaidi , Analia Lesmana , Cameron M Scott , Paul Ioannidis , Hina Kalra , Shivakumar Keerthikumar , Lars Tögel , Angela Rigopoulos , Sylvia J Gong , David S Williams , Prusoth Yoganantharaja , Kim Bell-Anderson , Suresh Mathivanan , Yann Gibert , Scott Hiebert , Andrew M Scott , Matthew J Watt , John M Mariadason

Mast Cell-Derived SAMD14 Is a Novel Regulator of the Human Prostate Tumor Microenvironment.

Cancers

Avec: Linda K H Teng , Brooke A Pereira , Shivakumar Keerthikumar , Cheng Huang , Birunthi Niranjan , Sophie N Lee , Michelle Richards , Ralf B Schittenhelm , Luc Furic , David L Goode , Mitchell G Lawrence , Renea A Taylor , Stuart J Ellem , Gail P Risbridger , Natalie L Lister

Multi-substrate Metabolic Tracing Reveals Marked Heterogeneity and Dependency on Fatty Acid Metabolism in Human Prostate Cancer.

Molecular cancer research : MCR

Avec: Gio Fidelito , David P De Souza , Birunthi Niranjan , William De Nardo , Shivakumar Keerthikumar , Kristin Brown , Renea A Taylor , Matthew J Watt

Réseau de co-auteurs

Suresh Mathivanan 4 collaborations

Gail P Risbridger 4 collaborations

David L Goode 4 collaborations

Birunthi Niranjan 4 collaborations

Renea A Taylor 4 collaborations

Pamali Fonseka 3 collaborations

Lahiru Gangoda 3 collaborations

Ching-Seng Ang 3 collaborations

Christopher G Adda 3 collaborations

Luc Furic 3 collaborations

Hina Kalra 3 collaborations

Mitchell G Lawrence 3 collaborations

Monisha Samuel 2 collaborations

Sai V Chitti 2 collaborations

David Chisanga 2 collaborations

Sean C Warren 2 collaborations

Kening Zhao 2 collaborations

Stephanie Boukouris 2 collaborations

Lanzhou Jiang 2 collaborations

Ivan K Poon 2 collaborations

Paul Timpson 2 collaborations

Edmond M Kwan 2 collaborations

Arun A Azad 2 collaborations

John Pedersen 2 collaborations

Michael Liem 2 collaborations

Haidar Al Saffar 2 collaborations

Laura H Porter 2 collaborations

Natalie L Lister 2 collaborations

Linda Teng 2 collaborations

Nicholas Choo 2 collaborations

Matthew J Watt 2 collaborations

Rahul Sanwlani 1 collaboration

Sing Ho Chee 1 collaboration

Alex Spurling 1 collaboration

Damien Zanker 1 collaboration

Ishara Atukorala 1 collaboration

Taeyoung Kang 1 collaboration

Sanjay Shahi 1 collaboration

Akbar L Marzan 1 collaboration

Christina Nedeva 1 collaboration

Claire Vennin 1 collaboration

Morghan C Lucas 1 collaboration

Lesley Cheng 1 collaboration

David Herrmann 1 collaboration

Mohashin Pathan 1 collaboration

Nidhi Abraham 1 collaboration

Sushma Anand 1 collaboration

Tanmay M Shekhar 1 collaboration

Nikola Baschuk 1 collaboration

Christine J Hawkins 1 collaboration

Amelia J Johnston 1 collaboration

Jacqueline Monique Orian 1 collaboration

Nicholas J Hoogenraad 1 collaboration

Andrew F Hill 1 collaboration

Markandeya Jois 1 collaboration

Belinda S Parker 1 collaboration

Heidi Fettke 1 collaboration

Jason A Steen 1 collaboration

Patricia Bukczynska 1 collaboration

David Goode 1 collaboration

Maria Docanto 1 collaboration

Nicole Ng 1 collaboration

Luciano Martelotto 1 collaboration

Christine Hauser 1 collaboration

Melissa C Southey 1 collaboration

Tu Nguyen-Dumont 1 collaboration

Marianna Volpert 1 collaboration

Jinghua Hu 1 collaboration

Anne E O'Connor 1 collaboration

Richard J Rebello 1 collaboration

Jemma Evans 1 collaboration

D Jo Merriner 1 collaboration

Peter McIntyre 1 collaboration

Moira K O'Bryan 1 collaboration

Arcadi Cipponi 1 collaboration

Justin Bedo 1 collaboration

Mark J McCabe 1 collaboration

Marina Pajic 1 collaboration

David R Croucher 1 collaboration

Alvaro Gonzalez Rajal 1 collaboration

Simon R Junankar 1 collaboration

Darren N Saunders 1 collaboration

Pavel Lobachevsky 1 collaboration

Anthony T Papenfuss 1 collaboration

Danielle Nessem 1 collaboration

Max Nobis 1 collaboration

Mark Cowley 1 collaboration

Ana C Vargas 1 collaboration

Min R Qiu 1 collaboration

Daniele G Generali 1 collaboration

Uyen Nguyen 1 collaboration

Niall M Corcoran 1 collaboration

Georgina V Long 1 collaboration

Jean-Yves Blay 1 collaboration

David M Thomas 1 collaboration

Christine Collins 1 collaboration

Ashlee K Clark 1 collaboration

Roxanne Toivanen 1 collaboration

Andrew Bakshi 1 collaboration

David Pook 1 collaboration

Carmel J Pezaro 1 collaboration

Shahneen Sandhu 1 collaboration

Rosalia Quezada Urban 1 collaboration

Melissa Papargiris 1 collaboration

Jenna Kraska 1 collaboration

Heather B Madsen 1 collaboration

Hong Wang 1 collaboration

Michelle G Richards 1 collaboration

Samantha O'Dea 1 collaboration

William Wheelahan 1 collaboration

Zhuoer Li 1 collaboration

John F Ouyang 1 collaboration

Heather Thorne 1 collaboration

Lisa Devereux 1 collaboration

Rodney J Hicks 1 collaboration

Shomik Sengupta 1 collaboration

Laurence Harewood 1 collaboration

Mahesh Iddawala 1 collaboration

Jeremy Goad 1 collaboration

Jeremy Grummet 1 collaboration

John Kourambas 1 collaboration

Daniel Moon 1 collaboration

Declan G Murphy 1 collaboration

David Clouston 1 collaboration

Sam Norden 1 collaboration

Andrew Ryan 1 collaboration

Mark Frydenberg 1 collaboration

L H Porter 1 collaboration

J J Zhu 1 collaboration

N L Lister 1 collaboration

S G Harrison 1 collaboration

S Keerthikumar 1 collaboration

D L Goode 1 collaboration

R Quezada Urban 1 collaboration

D J Byrne 1 collaboration

A Azad 1 collaboration

I Vela 1 collaboration

M S Hofman 1 collaboration

P J Neeson 1 collaboration

P K Darcy 1 collaboration

J A Trapani 1 collaboration

R A Taylor 1 collaboration

G P Risbridger 1 collaboration

Susanne Ramm 1 collaboration

Daisaku Ashikari 1 collaboration

Shelley Hedwards 1 collaboration

Kaylene J Simpson 1 collaboration

Mark Bleackley 1 collaboration

Kuok Yap 1 collaboration

Peter Lock 1 collaboration

Vincent Bulone 1 collaboration

Marilyn Anderson 1 collaboration

Mercedes Dávalos-Salas 1 collaboration

Magdalene K Montgomery 1 collaboration

Camilla M Reehorst 1 collaboration

Rebecca Nightingale 1 collaboration

Irvin Ng 1 collaboration

Holly Anderton 1 collaboration

Sheren Al-Obaidi 1 collaboration

Analia Lesmana 1 collaboration

Cameron M Scott 1 collaboration

Paul Ioannidis 1 collaboration

Lars Tögel 1 collaboration

Angela Rigopoulos 1 collaboration

Sylvia J Gong 1 collaboration

David S Williams 1 collaboration

Prusoth Yoganantharaja 1 collaboration

Kim Bell-Anderson 1 collaboration

Yann Gibert 1 collaboration

Scott Hiebert 1 collaboration

Andrew M Scott 1 collaboration

John M Mariadason 1 collaboration

Linda K H Teng 1 collaboration

Brooke A Pereira 1 collaboration

Cheng Huang 1 collaboration

Sophie N Lee 1 collaboration

Michelle Richards 1 collaboration

Ralf B Schittenhelm 1 collaboration

Stuart J Ellem 1 collaboration

Gio Fidelito 1 collaboration

David P De Souza 1 collaboration

William De Nardo 1 collaboration

Kristin Brown 1 collaboration