Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population.

Antigens, CD / genetics Breast Neoplasms / genetics Case-Control Studies Cell Adhesion Molecules, Neuronal / genetics Chloride Channels / genetics Chromosome Mapping Core Binding Factor Alpha 2 Subunit / genetics Female Fetal Proteins / genetics Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study / methods Humans Japan Linkage Disequilibrium Polymorphism, Single Nucleotide

Journal

Scientific reports

ISSN: 2045-2322

Titre abrégé: Sci Rep

Pays: England

ID NLM: 101563288

Informations de publication

Date de publication:
22 11 2019

Historique:

received: 12 11 2018

accepted: 26 10 2019

entrez: 24 11 2019

pubmed: 24 11 2019

medline: 4 11 2020

Statut: epublish

Résumé

Genome-wide association studies (GWAS) have successfully identified about 70 genomic loci associated with breast cancer. Owing to the complexity of linkage disequilibrium and environmental exposures in different populations, it is essential to perform regional GWAS for better risk prediction. This study aimed to investigate the genetic architecture and to assess common genetic risk model of breast cancer with 6,669 breast cancer patients and 21,930 female controls in the Japanese population. This GWAS identified 11 genomic loci that surpass genome-wide significance threshold of P < 5.0 × 10

Identifiants

DOI: 10.1038/s41598-019-53654-9 PMID: 31757997 PMC: PMC6874604

pubmed: 31757997

doi: 10.1038/s41598-019-53654-9

pii: 10.1038/s41598-019-53654-9

pmc: PMC6874604

doi:

Substances chimiques

ALCAM protein, human 0

Antigens, CD 0

CLIC6 protein, human 0

Cell Adhesion Molecules, Neuronal 0

Chloride Channels 0

Core Binding Factor Alpha 2 Subunit 0

Fetal Proteins 0

RUNX1 protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

17332

Références

Nat Genet. 2013 Apr;45(4):353-61, 361e1-2

pubmed: 23535729

Anticancer Res. 2010 Apr;30(4):1163-8

pubmed: 20530423

PLoS Genet. 2010 Jun 24;6(6):e1001002

pubmed: 20585626

Am J Hum Genet. 2004 Jun;74(6):1175-82

pubmed: 15122511

Cancer Res. 2013 May 1;73(9):2840-9

pubmed: 23447579

PLoS One. 2016 Nov 2;11(11):e0165559

pubmed: 27806084

Nature. 1995 Dec 21-28;378(6559):789-92

pubmed: 8524414

Carcinogenesis. 2014 May;35(5):1012-9

pubmed: 24325915

Am J Hum Genet. 2013 Oct 3;93(4):687-96

pubmed: 24094745

Breast Cancer Res Treat. 2011 Apr;126(3):717-27

pubmed: 20872241

Nat Genet. 2013 Apr;45(4):392-8, 398e1-2

pubmed: 23535733

Hum Mol Genet. 2016 Aug 1;25(15):3361-3371

pubmed: 27354352

Nat Genet. 2010 Oct;42(10):885-92

pubmed: 20852631

Fam Cancer. 2011 Jun;10(2):225-31

pubmed: 21365267

Nat Commun. 2014 Oct 20;5:5260

pubmed: 25327703

Jpn J Clin Oncol. 2014 Sep;44(9):777-82

pubmed: 25104790

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4340-5

pubmed: 18326623

Nat Genet. 2006 Aug;38(8):873-5

pubmed: 16832357

Hum Mol Genet. 2011 Dec 15;20(24):4991-9

pubmed: 21908515

Nat Genet. 2012 Jul 22;44(8):955-9

pubmed: 22820512

Oncology. 2012;82(6):305-12

pubmed: 22555284

PLoS One. 2013 Oct 15;8(10):e76463

pubmed: 24143190

Nat Genet. 2014 Aug;46(8):886-90

pubmed: 25038754

Gene Expr Patterns. 2011 Jun-Jul;11(5-6):327-33

pubmed: 21402173

Nature. 2012 Oct 4;490(7418):61-70

pubmed: 23000897

Nat Genet. 1997 May;16(1):64-7

pubmed: 9140396

Nat Genet. 2012 Nov;44(11):1182-4

pubmed: 23001122

Mol Cancer. 2013 Sep 22;12(1):106

pubmed: 24053408

Nature. 2012 Jun 20;486(7403):405-9

pubmed: 22722202

Cancer Epidemiol Biomarkers Prev. 2014 Apr;23(4):658-69

pubmed: 24493630

Nat Commun. 2014 Aug 07;5:4577

pubmed: 25099679

Nat Genet. 2004 Apr;36(4):388-93

pubmed: 15052270

Nature. 2007 Jun 28;447(7148):1087-93

pubmed: 17529967

Annu Rev Genomics Hum Genet. 2009;10:387-406

pubmed: 19715440

Nat Genet. 2007 Jul;39(7):870-4

pubmed: 17529973

J Natl Cancer Inst. 2011 Mar 2;103(5):425-35

pubmed: 21263130

Breast Cancer Res. 2012 Mar 27;14(2):R56

pubmed: 22452962

Nucleic Acids Res. 2019 Jan 8;47(D1):D1005-D1012

pubmed: 30445434

Nat Commun. 2016 Apr 27;7:11375

pubmed: 27117709

Nat Genet. 2009 May;41(5):579-84

pubmed: 19330030

Nat Genet. 2009 Mar;41(3):324-8

pubmed: 19219042

Nat Genet. 2011 Oct 30;43(12):1210-4

pubmed: 22037553

J Hum Genet. 2012 Dec;57(12):766-71

pubmed: 22951594

Mol Cell Biol. 2002 Jun;22(11):3610-20

pubmed: 11997498

Nat Genet. 2007 Jul;39(7):865-9

pubmed: 17529974

Bioinformatics. 2005 Jan 15;21(2):263-5

pubmed: 15297300

Hum Mol Genet. 2016 Nov 1;25(21):4835-4846

pubmed: 28171663

Nat Commun. 2013;4:2464

pubmed: 24043118

Nat Rev Cancer. 2015 Oct;15(10):608-24

pubmed: 26383140

PLoS Genet. 2012;8(2):e1002532

pubmed: 22383897

Hum Mol Genet. 2008 Oct 15;17(R2):R122-8

pubmed: 18852200

PLoS Genet. 2010 Aug 12;6(8):

pubmed: 20714348

Hum Mol Genet. 2012 Dec 15;21(24):5373-84

pubmed: 22976474

Nat Genet. 2006 Aug;38(8):904-9

pubmed: 16862161

J Epidemiol. 2017 Mar;27(3S):S58-S64

pubmed: 28223083

Am J Hum Genet. 2008 Oct;83(4):445-56

pubmed: 18817904

Nat Genet. 2017 Jun;49(6):953-958

pubmed: 28416822

Science. 1994 Oct 7;266(5182):66-71

pubmed: 7545954

Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2523-31

pubmed: 25546839

Nature. 2017 Nov 2;551(7678):92-94

pubmed: 29059683

J Biol Chem. 2006 Feb 3;281(5):2750-6

pubmed: 16316993

Cancer. 2014 Nov 15;120(22):3446-56

pubmed: 24948110

PLoS Genet. 2010 Oct 28;6(10):e1001183

pubmed: 21060860

Carcinogenesis. 2016 Aug;37(8):741-750

pubmed: 27236187

Cancer Lett. 2013 May 28;332(2):133-40

pubmed: 20817393

Nat Genet. 2010 Jun;42(6):504-7

pubmed: 20453838