Polyomavirus-Positive Merkel Cell Carcinoma Derived from a Trichoblastoma Suggests an Epithelial Origin of this Merkel Cell Carcinoma.
Aged
Carcinogenesis
Carcinoma, Merkel Cell
/ diagnosis
Cell Differentiation
Cell Lineage
Hair Follicle
/ pathology
High-Throughput Nucleotide Sequencing
Humans
Male
Mutation
/ genetics
Neoplasms
/ diagnosis
Polyomavirus
/ physiology
Polyomavirus Infections
/ diagnosis
Skin
/ pathology
Skin Neoplasms
/ diagnosis
Tumor Virus Infections
Virus Integration
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
27
05
2019
revised:
22
08
2019
accepted:
19
09
2019
pubmed:
25
11
2019
medline:
7
1
2021
entrez:
25
11
2019
Statut:
ppublish
Résumé
Merkel cell carcinoma (MCC), an aggressive neuroendocrine carcinoma of the skin, is to date the only human cancer known to be frequently caused by a polyomavirus. However, it is a matter of debate which cells are targeted by the Merkel cell polyomavirus (MCPyV) to give rise to the phenotypically multifaceted MCC cells. To assess the lineage of origin of MCPyV-positive MCC, genetic analysis of a very rare tumor combining benign trichoblastoma and MCPyV-positive MCC was conducted by massive parallel sequencing. Although MCPyV was found to be integrated only in the MCC part, six somatic mutations were shared by both tumor components. The mutational overlap between the trichoblastoma and MCPyV-positive MCC parts of the combined tumor implies that MCPyV integration occurred in an epithelial tumor cell before MCC development. Therefore, our report demonstrates that MCPyV-positive MCC can derive from the epithelial lineage.
Identifiants
pubmed: 31759946
pii: S0022-202X(19)33387-1
doi: 10.1016/j.jid.2019.09.026
pii:
doi:
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
976-985Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.