Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions.
Apolipoprotein E
C-reactive protein
Delirium
Gene-protein interaction
Inflammation
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
pubmed:
26
11
2019
medline:
27
11
2020
entrez:
26
11
2019
Statut:
ppublish
Résumé
Apolipoprotein E (APOE) status may modify the risk of postoperative delirium conferred by inflammation. We tested whether APOE modifies the established association between C-reactive protein (CRP) and delirium incidence, severity, and duration in 553 noncardiac surgical patients aged 70 and older. High postoperative plasma CRP (≥234.12 mg/L) was defined by the highest sample-based quartile. Delirium was determined using the Confusion Assessment Method and chart review, and severity was determined by the Confusion Assessment Method-Severity score. APOE ε4 carrier prevalence was 19%, and postoperative delirium occurred in 24%. The relationship between CRP and delirium incidence, severity, and duration differed by ε4 status. Among ε4 carriers, there was a strong relationship between high CRP (vs. low CRP) and delirium incidence (relative risk [95% confidence interval], 3.0 [1.4-6.7]); however, no significant association was observed among non-ε4 carriers (relative risk [95% CI], 1.2 [0.8-1.7]). Our findings raise the possibility that APOE ε4 carrier status may modify the relationship between postoperative day 2 CRP levels and postoperative delirium.
Identifiants
pubmed: 31761478
pii: S1552-5260(19)35476-7
doi: 10.1016/j.jalz.2019.09.080
pmc: PMC7086383
mid: NIHMS1567021
doi:
Substances chimiques
Apolipoprotein E4
0
Apolipoproteins E
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
572-580Subventions
Organisme : NIA NIH HHS
ID : R01 AG051658
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG041274
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG035075
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062421
Pays : United States
Organisme : NIA NIH HHS
ID : K07 AG041835
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031720
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG048600
Pays : United States
Organisme : Alzheimer's Association
Pays : International
Organisme : NIA NIH HHS
ID : R03 AG061582
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG057836
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG057955
Pays : United States
Organisme : NIA NIH HHS
ID : R24 AG054259
Pays : United States
Informations de copyright
© 2019 the Alzheimer's Association.
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