Prognostic value of diffusion-weighted magnetic resonance imaging of brain in fetal growth restriction: results of prospective multicenter study.
Adult
Brain
/ diagnostic imaging
Diffusion Magnetic Resonance Imaging
/ methods
Female
Fetal Growth Retardation
/ diagnostic imaging
Fetal Weight
Gestational Age
Humans
Infant, Small for Gestational Age
Predictive Value of Tests
Pregnancy
Pregnancy Outcome
/ epidemiology
Pregnancy Trimester, Third
Prenatal Diagnosis
/ methods
Prognosis
Prospective Studies
Ultrasonography, Doppler
Ultrasonography, Prenatal
Umbilical Arteries
/ diagnostic imaging
FGR
IUGR
SGA
diffusion-weighted imaging
fetal growth restriction
intrauterine growth restriction
perinatal outcome
small-for-gestational age
Journal
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
ISSN: 1469-0705
Titre abrégé: Ultrasound Obstet Gynecol
Pays: England
ID NLM: 9108340
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
27
06
2019
revised:
08
11
2019
accepted:
15
11
2019
pubmed:
26
11
2019
medline:
1
12
2021
entrez:
26
11
2019
Statut:
ppublish
Résumé
To measure prospectively apparent diffusion coefficient (ADC) values between 28 and 32 weeks of gestation in different cerebral territories of fetuses with estimated fetal weight (EFW) ≤ 5 This was a prospective study involving six tertiary-level perinatal centers. In the period 22 November 2016 to 11 September 2017, we included singleton, small-for-gestational-age (SGA) fetuses with EFW ≤ 5 MRI was performed in 64 patients, of whom five were excluded owing to fetal movement artifacts on DWI and two were excluded for termination of pregnancy with no link to fetal growth restriction (FGR). One intrauterine death occurred secondary to severe FGR. Among the 56 liveborn neonates, delivered at a mean ± SD gestational age of 33.6 ± 3.0 weeks, with a mean birth weight of 1441 ± 566 g, four neonatal deaths occurred. In addition, two neonates required prolonged mechanical ventilation, one of whom also developed necrotizing enterocolitis. Overall, therefore, seven out of 57 (12.3%) cases had an adverse perinatal outcome (95% CI, 3.8-20.8%). The ADC values in the frontal region were significantly lower in the group with adverse perinatal outcome vs those in the group with favorable outcome (mean values of both hemispheres, 1.68 vs 1.78 × 10 This first prospective, multicenter, cohort study using DWI in the setting of SGA found lower ADC values in the frontal white-matter territory in fetuses with, compared with those without, adverse perinatal outcome. To determine the prognostic value of these changes, further standardized evaluation of the neurodevelopment of children born with growth restriction is required. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Types de publication
Evaluation Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
893-900Informations de copyright
Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Références
Boulet SL, Alexander GR, Salihu HM, Kirby RS, Carlo WA. Fetal growth risk curves: defining levels of fetal growth restriction by neonatal death risk. Am J Obstet Gynecol 2006; 195: 1571-1577.
Aucott SW, Donohue PK, Northington FJ. Increased morbidity in severe early intrauterine growth restriction. J Perinatol 2004; 24: 435-440.
McIntire DD, Bloom SL, Casey BM, Leveno KJ. Birth weight in relation to morbidity and mortality among newborn infants. N Engl J Med 1999; 340: 1234-1238.
Pilliod RA, Cheng YW, Snowden JM, Doss AE, Caughey AB. The risk of intrauterine fetal death in the small-for-gestational-age fetus. Am J Obstet Gynecol 2012; 207: 318.e1-6.
Levine TA, Grunau RE, McAuliffe FM, Pinnamaneni R, Foran A, Alderdice FA. Early childhood neurodevelopment after intrauterine growth restriction: a systematic review. Pediatrics 2015; 135: 126-141.
Pasupathy D, Wood AM, Pell JP, Fleming M, Smith GC. Rates of and factors associated with delivery-related perinatal death among term infants in Scotland. JAMA 2009; 302: 660-668.
McIntyre S, Blair E, Badawi N, Keogh J, Nelson KB. Antecedents of cerebral palsy and perinatal death in term and late preterm singletons. Obstet Gynecol 2013; 122: 869-877.
Baschat AA. Planning management and delivery of the growth-restricted fetus. Best Pract Res Clin Obstet Gynaecol 2018; 49: 53-65.
Eikenes L, Løhaugen GC, Brubakk AM, Skranes J, Håberg AK. Young adults born preterm with very low birth weight demonstrate widespread white matter alterations on brain DTI. Neuroimage 2011; 54: 1774-1785.
Grunewaldt KH, Fjørtoft T, Bjuland KJ, Brubakk AM, Eikenes L, Håberg AK, Løhaugen GC, Skranes J. Follow-up at age 10 years in ELBW children - functional outcome, brain morphology and results from motor assessments in infancy. Early Hum Dev 2014; 90: 571-578.
Rutherford M, Biarge MM, Allsop J, Counsell S, Cowan F. MRI of perinatal brain injury. Pediatr Radiol 2010; 40: 819-833.
de Vries LS, Groenendaal F. Patterns of neonatal hypoxic-ischaemic brain injury. Neuroradiology 2010; 52: 555-566.
Rutherford M, Malamateniou C, McGuinness A, Allsop J, Biarge MM, Counsell S. Magnetic resonance imaging in hypoxic-ischaemic encephalopathy. Early Hum Dev 2010; 86: 351-360.
Ramenghi LA, Rutherford M, Fumagalli M, Bassi L, Messner H, Counsell S, Mosca F. Neonatal neuroimaging: going beyond the pictures. Early Hum Dev 2009; 85: S75-77.
Liauw L, van Wezel-Meijler G, Veen S, van Buchem MA, van der Grond J. Do apparent diffusion coefficient measurements predict outcome in children with neonatal hypoxic-ischemic encephalopathy? AJNR Am J Neuroradiol 2009; 30: 264-270.
Cowan FM, Pennock JM, Hanrahan JD, Manji KP, Edwards AD. Early detection of cerebral infarction and hypoxic ischemic encephalopathy in neonates using diffusion-weighted magnetic resonance imaging. Neuropediatrics 1994; 25: 172-175.
Schneider JF, Confort-Gouny S, Le Fur Y, Viout P, Bennathan M, Chapon F, Fogliarini C, Cozzone P, Girard N. Diffusion-weighted imaging in normal fetal brain maturation. Eur Radiol 2007; 17: 2422-2429.
Sartor A, Arthurs O, Alberti C, Belarbi N, Tilea B, Boizeau P, Oury JF, Elmaleh-Berges M, Gressens P, Sebag G, Alison M. Apparent diffusion coefficient measurements of the fetal brain during the third trimester of pregnancy: how reliable are they in clinical practice? Prenat Diagn 2014; 34: 357-366.
Sanz-Cortés M, Figueras F, Bargalló N, Padilla N, Amat-Roldan I, Gratacós E. Abnormal brain microstructure and metabolism in small-for-gestational-age term fetuses with normal umbilical artery Doppler. Ultrasound Obstet Gynecol 2010; 36: 159-165.
Arthurs OJ, Rega A, Guimiot F, Belarbi N, Rosenblatt J, Biran V, Elmaleh M, Sebag G, Alison M. Diffusion-weighted magnetic resonance imaging of the fetal brain in intrauterine growth restriction. Ultrasound Obstet Gynecol 2017; 50: 79-87.
Kutuk MS, Sahin M, Gorkem SB, Doganay S, Ozturk A. Relationship between Doppler findings and fetal brain apparent diffusion coefficient in early-onset intra-uterine growth restriction. J Matern Fetal Neonatal Med 2018; 31: 3201-3208.
Abdel Razek AAK1, Thabet M, Salam EA. Apparent Diffusion Coefficient of the Placenta and Fetal Organs in Intrauterine Growth Restriction. J Comput Assist Tomogr 2019; 43: 507-512.
Robinson HP, Fleming JE. A critical evaluation of sonar “crown-rump length” measurements. Br J Obstet Gynaecol 1975; 82: 702-710.
Hadlock FP, Harrist RB, Martinez-Poyer J. In utero analysis of fetal growth: a sonographic weight standard. Radiology 1991; 181: 129-133.
French College of Gynecologists and Obstetricians. Intra-uterine growth retardation: guidelines for clinical practice. J Gynecol Obstet Biol Reprod 2013; 42: 1018-1025.
Kurmanavicius J, Florio I, Wisser J, Hebisch G, Zimmermann R, Müller R, Huch R, Huch A. Reference resistance indices of the umbilical, fetal middle cerebral and uterine arteries at 24-42 weeks of gestation. Ultrasound Obstet Gynecol 1997; 10: 112-120.
Ananth CV, Schisterman EF. Confounding, causality, and confusion: the role of intermediate variables in interpreting observational studies in obstetrics. Am J Obstet Gynecol 2017; 217: 167-175.
Alfirevic Z, Stampalija T, Dowswell T. Fetal and umbilical Doppler ultrasound in high-risk pregnancies. Cochrane Database Syst Rev 2017; 6: CD007529.
Unterscheider J, Daly S, Geary MP, Kennelly MM, McAuliffe FM, O'Donoghue K, Hunter A, Morrison JJ, Burke G, Dicker P, Tully EC, Malone FD. Predictable progressive Doppler deterioration in IUGR: does it really exist? Am J Obstet Gynecol 2013; 209: 539.e1-7.
Unterscheider J, Daly S, Geary MP, Kennelly MM, McAuliffe FM, O'Donoghue K, Hunter A, Morrison JJ, Burke G, Dicker P, Tully EC, Malone FD. Optimizing the definition of intrauterine growth restriction: the multicenter prospective PORTO Study. Am J Obstet Gynecol 2013; 208: 290.e1-6.
Lees C, Marlow N, Arabin B, Bilardo CM, Brezinka C, Derks JB, Duvekot J, Frusca T, Diemert A, Ferrazzi E, Ganzevoort W, Hecher K, Martinelli P, Ostermayer E, Papageorghiou AT, Schlembach D, Schneider KT, Thilaganathan B, Todros T, van Wassenaer-Leemhuis A, Valcamonico A, Visser GH, Wolf H; TRUFFLE Group. Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE). Ultrasound Obstet Gynecol 2013; 42: 400-408.
Ganzevoort W, Mensing Van Charante N, Thilaganathan B, Prefumo F, Arabin B, Bilardo CM, Brezinka C, Derks JB, Diemert A, Duvekot JJ, Ferrazzi E, Frusca T, Hecher K, Marlow N, Martinelli P, Ostermayer E, Papageorghiou AT, Schlembach D, Schneider KTM, Todros T, Valcamonico A, Visser GHA, Van Wassenaer-Leemhuis A, Lees CC, Wolf H, on behalf of the TRUFFLE Group. How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks: post-hoc analysis of TRUFFLE study. Ultrasound Obstet Gynecol 2017; 49: 769-777.
Ganzevoort W, Thornton JG, Marlow N, Thilaganathan B, Arabin B, Prefumo F, Lees C, Wolf H, GRIT Study Group; TRUFFLE Study Group. Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials. Ultrasound Obstet Gynecol 2020; 55: 68-74.
Schneider MM, Berman JI, Baumer FM, Glass HC, Jeng S, Jeremy RJ, Esch M, Biran V, Barkovich AJ, Studholme C, Xu D, Glenn OA. Normative apparent diffusion coefficient values in the developing fetal brain. AJNR Am J Neuroradiol 2009; 30: 1799-1803.
Cannie M, De Keyzer F, Meersschaert J, Jani J, Lewi L, Deprest J, Dymarkowski S, Demaerel P. A diffusion-weighted template for gestational age-related apparent diffusion coefficient values in the developing fetal brain. Ultrasound Obstet Gynecol 2007; 30: 318-324.
Bui T, Daire JL, Chalard F, Zaccaria I, Alberti C, Elmaleh M, Garel C, Luton D, Blanc N, Sebag G. Microstructural development of human brain assessed in utero by diffusion tensor imaging. Pediatr Radiol 2006; 36: 1133-1140.