Comparative binding and uptake of liposomes decorated with mannose oligosaccharides by cells expressing the mannose receptor or DC-SIGN.
Binding Sites
Cell Adhesion Molecules
/ chemistry
Cells, Cultured
Dendritic Cells
HEK293 Cells
Humans
Lectins, C-Type
/ chemistry
Liposomes
/ chemistry
Mannose
/ chemistry
Mannose Receptor
Mannose-Binding Lectins
/ chemistry
Molecular Structure
Oligosaccharides
/ chemistry
Receptors, Cell Surface
/ chemistry
DC-SIGN
Dendritic cells
Glycolipids
Liposomes
Mannose receptor
Oligosaccharides
Journal
Carbohydrate research
ISSN: 1873-426X
Titre abrégé: Carbohydr Res
Pays: Netherlands
ID NLM: 0043535
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
27
08
2019
revised:
08
11
2019
accepted:
11
11
2019
pubmed:
26
11
2019
medline:
4
2
2021
entrez:
26
11
2019
Statut:
ppublish
Résumé
Mannose Receptor (MR) and DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) are two mannose-specific targets for antigens carried by liposomes but DC-SIGN is more specific of DCs. Here, DC targeting is addressed by using DPPC/DOPE liposomes decorated with a series of diether lipids with a polar head of either a mannose (Man), tri-antenna of α-d-mannopyranoside (Tri-Man), [Manα1-3(Manα1-6)Man] (Man-tri), pseudo-Man
Identifiants
pubmed: 31766009
pii: S0008-6215(19)30510-5
doi: 10.1016/j.carres.2019.107877
pii:
doi:
Substances chimiques
Cell Adhesion Molecules
0
DC-specific ICAM-3 grabbing nonintegrin
0
Lectins, C-Type
0
Liposomes
0
Mannose Receptor
0
Mannose-Binding Lectins
0
Oligosaccharides
0
Receptors, Cell Surface
0
Mannose
PHA4727WTP
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107877Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.