A CMOS NMR needle for probing brain physiology with high spatial and temporal resolution.
Journal
Nature methods
ISSN: 1548-7105
Titre abrégé: Nat Methods
Pays: United States
ID NLM: 101215604
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
20
12
2018
accepted:
07
10
2019
pubmed:
27
11
2019
medline:
14
4
2020
entrez:
27
11
2019
Statut:
ppublish
Résumé
Magnetic resonance imaging and spectroscopy are versatile methods for probing brain physiology, but their intrinsically low sensitivity limits the achievable spatial and temporal resolution. Here, we introduce a monolithically integrated NMR-on-a-chip needle that combines an ultra-sensitive 300 µm NMR coil with a complete NMR transceiver, enabling in vivo measurements of blood oxygenation and flow in nanoliter volumes at a sampling rate of 200 Hz.
Identifiants
pubmed: 31768059
doi: 10.1038/s41592-019-0640-3
pii: 10.1038/s41592-019-0640-3
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-67Références
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