Versatile symport transporters based on cyclic peptide dimers.

Calcium / metabolism Chlorides / metabolism Hydrogen-Ion Concentration Ionophores / chemical synthesis Lipid Bilayers / metabolism Peptides, Cyclic / chemical synthesis Pyridines / chemical synthesis Unilamellar Liposomes / metabolism

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
17 Dec 2019
Historique:
pubmed: 27 11 2019
medline: 28 12 2019
entrez: 27 11 2019
Statut: ppublish

Résumé

We present the synthesis and transmembrane transport properties of a new family of tris-pyridine-decorated cyclic peptides. These molecules are designed to self-assemble into dimeric shuttles in nonpolar media, which act as symport ionophores in which, apparently, the tris-pyridine scaffold complexes both cations and anions with high potency and efficacy.

Identifiants

DOI: 10.1039/c9cc06644f PMID: 31768506
pubmed: 31768506
doi: 10.1039/c9cc06644f
doi:

Substances chimiques

Chlorides 0
Ionophores 0
Lipid Bilayers 0
Peptides, Cyclic 0
Pyridines 0
Unilamellar Liposomes 0
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

46-49

Auteurs

Alberto Fuertes (A)

Singular Research Centre in Chemical Biology and Molecular Materials, (CIQUS), Organic Chemistry Department, University of Santiago de Compostela (USC), 15782, Santiago de Compostela, Spain. manuel.amorin@usc.es juanr.granja@usc.es.

Manuel Amorín (M)

Juan R Granja (JR)

Articles similaires

Initial pH determines the morphological characteristics and secondary metabolite production in Aspergillus terreus and Streptomyces rimosus cocultures.

Tomasz Boruta, Martyna Foryś, Weronika Pawlikowska et al.
1.00
Aspergillus Hydrogen-Ion Concentration Coculture Techniques Secondary Metabolism Streptomyces rimosus

Trace elements in psoriasis presentation and treatment.

Pratiksha Patra, Tyler Harrison
1.00
Psoriasis Humans Magnesium Zinc Trace Elements

Conservation of the cooling agent binding pocket within the TRPM subfamily.

Kate Huffer, Matthew C S Denley, Elisabeth V Oskoui et al.
1.00
TRPM Cation Channels Animals Binding Sites Mice Pyrimidinones

Analysis of vitamin D metabolism, thyroid and autoimmune markers in the vitiligo pathways and their possible interaction with sleep.

Ellen M S Xerfan, Monica L Andersen, Sergio Tufik et al.
1.00
Humans Vitiligo Male Female Adult

Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Versatile symport transporters based on cyclic...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › Versatile symport transporters based on cyclic...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Versatile symport transporters based on cyclic...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Ionophores › Versatile symport transporters based on cyclic...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Double couche lipidique › Versatile symport transporters based on cyclic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Versatile symport transporters based on cyclic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Versatile symport transporters based on cyclic...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Liposomes unilamellaires › Versatile symport transporters based on cyclic...