Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
12
03
2019
accepted:
06
11
2019
pubmed:
30
11
2019
medline:
15
2
2020
entrez:
29
11
2019
Statut:
ppublish
Résumé
The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment of malaria has relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective against intra-erythrocytic asexual blood-stage parasites, until resistance arose in Southeast Asia and South America and spread worldwide
Identifiants
pubmed: 31776516
doi: 10.1038/s41586-019-1795-x
pii: 10.1038/s41586-019-1795-x
pmc: PMC6911266
mid: NIHMS1541931
doi:
Substances chimiques
Membrane Transport Proteins
0
PfCRT protein, Plasmodium falciparum
0
Protozoan Proteins
0
Quinolines
0
Chloroquine
886U3H6UFF
piperaquine
A0HV2Q956Y
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
315-320Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL120826
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103310
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM116799
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI050612
Pays : United States
Organisme : NCRR NIH HHS
ID : P41 RR001209
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM111980
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117372
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI111962
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM119396
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM132120
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI050234
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147628
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI106711
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124678
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI109023
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI056312
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI050234
Pays : United States
Commentaires et corrections
Type : CommentIn
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