Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters.
Acebutolol
/ chemistry
Adrenergic Agonists
/ chemistry
Adrenergic Antagonists
/ chemistry
Atenolol
/ chemistry
Biological Transport
Fenoterol
/ chemistry
Formoterol Fumarate
/ chemistry
HEK293 Cells
Humans
Kinetics
Organic Cation Transport Proteins
/ agonists
Organic Cation Transporter 1
/ agonists
Organic Cation Transporter 2
/ agonists
Stereoisomerism
Beta-adrenergic drugs
Enantiomers
Organic cation transporters
SLC22A1
Solute carriers
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
01
10
2019
accepted:
22
11
2019
pubmed:
30
11
2019
medline:
28
7
2020
entrez:
30
11
2019
Statut:
ppublish
Résumé
Stereoselectivity is well described for receptor binding and enzyme catalysis, but so far has only been scarcely investigated in carrier-mediated membrane transport. We thus studied transport kinetics of racemic (anti)adrenergic drugs by the organic cation transporters OCT1 (wild-type and allelic variants), OCT2, OCT3, MATE1, and MATE2-K with a focus on stereospecificity. OCT1 showed stereoselective uptake with up to 2-fold higher v
Identifiants
pubmed: 31783011
pii: S0006-2952(19)30430-7
doi: 10.1016/j.bcp.2019.113731
pii:
doi:
Substances chimiques
Adrenergic Agonists
0
Adrenergic Antagonists
0
Organic Cation Transport Proteins
0
Organic Cation Transporter 1
0
Organic Cation Transporter 2
0
Fenoterol
22M9P70OQ9
Atenolol
50VV3VW0TI
Acebutolol
67P356D8GH
Formoterol Fumarate
W34SHF8J2K
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113731Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.