Molecular evolution of the hemagglutinin-neuraminidase (HN) gene in human respirovirus 3.
Bioinformatic analysis
Conformational epitope
Hemagglutinin-neuraminidase (HN) gene
Human respirovirus 3
Molecular evolution
Journal
Virus research
ISSN: 1872-7492
Titre abrégé: Virus Res
Pays: Netherlands
ID NLM: 8410979
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
22
09
2019
revised:
08
11
2019
accepted:
25
11
2019
pubmed:
30
11
2019
medline:
10
4
2021
entrez:
30
11
2019
Statut:
ppublish
Résumé
Human respirovirus 3 (HRV3) is a major causative agent of acute respiratory infections in humans. HRV3 can manifest as a recurrent infection, although exactly how is not known. In the present study, we conducted detailed molecular evolutionary analyses of the major antigen-coding hemagglutinin-neuraminidase (HN) gene of this virus detected/isolated in various countries. We performed analyses of time-scaled evolution, similarity, selective pressure, phylodynamics, and conformational epitope prediction by mapping to HN protein models. In this way, we estimated that a common ancestor of the HN gene of HRV3 and bovine respirovirus 3 diverged around 1815 and formed many lineages in the phylogenetic tree. The evolutionary rates of the HN gene were 1.1 × 10
Identifiants
pubmed: 31783038
pii: S0168-1702(19)30683-5
doi: 10.1016/j.virusres.2019.197824
pii:
doi:
Substances chimiques
Epitopes
0
HN Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
197824Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that there are no conflicts of interests.