STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone.
Animals
Bone and Bones
/ abnormalities
Cancellous Bone
/ pathology
Cortical Bone
/ diagnostic imaging
Gingiva
/ growth & development
Hair
/ growth & development
Homozygote
Incisor
/ pathology
Kyphosis
/ genetics
Megakaryocytes
/ metabolism
Mice
Mutation
Osteoblasts
/ metabolism
Osteocytes
/ metabolism
Ribs
/ diagnostic imaging
Splenomegaly
/ pathology
Stromal Interaction Molecule 1
/ metabolism
Thorax
/ pathology
X-Ray Microtomography
Abnormal bone architecture
Ectopic hair growth
STIM1 R304W
Skeletal defects
Stormorken syndrome
Journal
Cell calcium
ISSN: 1532-1991
Titre abrégé: Cell Calcium
Pays: Netherlands
ID NLM: 8006226
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
13
07
2019
revised:
05
11
2019
accepted:
11
11
2019
pubmed:
1
12
2019
medline:
2
6
2021
entrez:
1
12
2019
Statut:
ppublish
Résumé
Calcium signaling plays a central role in bone development and homeostasis. Store operated calcium entry (SOCE) is an important calcium influx pathway mediated by calcium release activated calcium (CRAC) channels in the plasma membrane. Stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum calcium sensing protein important for SOCE. We generated a mouse model expressing the STIM1 R304W mutation, causing Stormorken syndrome in humans. Stim1
Identifiants
pubmed: 31785581
pii: S0143-4160(19)30177-0
doi: 10.1016/j.ceca.2019.102110
pii:
doi:
Substances chimiques
Stromal Interaction Molecule 1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102110Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR064211
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.