Effect of Yokukansan and Yokukansankachimpihange on Aggressive Behavior, 5-HT Receptors and Arginine Vasopressin Expression in Social Isolation-Reared Mice.
Aggression
/ drug effects
Amygdala
/ drug effects
Animals
Arginine Vasopressin
/ genetics
Behavior, Animal
/ drug effects
Drugs, Chinese Herbal
/ pharmacology
Hydroxyindoleacetic Acid
/ metabolism
Male
Mice
RNA, Messenger
/ metabolism
Receptors, Serotonin
/ genetics
Serotonin
/ metabolism
Social Isolation
aggressive behavior
arginine vasopressin
serotonin (5-HT)3A receptor
yokukansan
yokukansankachimpihange
Journal
Biological & pharmaceutical bulletin
ISSN: 1347-5215
Titre abrégé: Biol Pharm Bull
Pays: Japan
ID NLM: 9311984
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
3
12
2019
pubmed:
4
12
2019
medline:
10
4
2020
Statut:
ppublish
Résumé
The traditional herbal medicines yokukansan (YKS) and yokukansankachimpihange (YKSCH) are prescribed for neurosis, insomnia or night crying and irritability in children. YKSCH comprises YKS and two additional herbs, a chimpi and a hange, and is used to treat digestive function deficiencies. However, the differences between the effects of YKS and YKSCH on brain function are unclear. The present study examined the effects of YKS and YKSCH on aggressive behavior in mice reared under a social isolation (SI) condition. Mice were housed individually for 6 weeks. YKS and YKSCH were administered orally for 2 weeks before aggression tests. SI increased aggressive behavior against naïve mice, and YKS, but not YKSCH, significantly attenuated this aggressive behavior. Because serotonin (5-HT)
Identifiants
pubmed: 31787717
doi: 10.1248/bpb.b19-00499
doi:
Substances chimiques
Drugs, Chinese Herbal
0
RNA, Messenger
0
Receptors, Serotonin
0
Yi-Gan San
0
yokukansankachimpihange
0
Arginine Vasopressin
113-79-1
Serotonin
333DO1RDJY
Hydroxyindoleacetic Acid
54-16-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM