Caregiver burden and health-related quality of life in idiopathic dystonia patients under botulinum toxin treatment: a cross-sectional study.
Adult
Affective Symptoms
/ psychology
Aged
Aged, 80 and over
Anxiety
/ psychology
Botulinum Toxins
/ administration & dosage
Caregiver Burden
Cognitive Dysfunction
/ physiopathology
Cross-Sectional Studies
Depression
/ psychology
Dystonic Disorders
/ drug therapy
Female
Humans
Male
Middle Aged
Neuromuscular Agents
/ administration & dosage
Quality of Life
Anxiety
Botulinum toxin
Caregiver burden
Depression
Dystonia
Quality of life
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
27
08
2019
accepted:
25
11
2019
pubmed:
6
12
2019
medline:
27
3
2021
entrez:
6
12
2019
Statut:
ppublish
Résumé
Dystonia is a chronic movement disorder that is associated with a reduction in health-related quality of life (HR-QoL) and restriction of activities of daily living. Botulinum neurotoxin (BT) improves disease-specific HR-QoL by reducing abnormal movements, postures, and pain. We examined the burden of the corresponding primary caregiver as a potential important factor for disease management and HR-QoL of dystonia patients under treatment with BT. 114 patients with focal, segmental, or generalized dystonia were recruited, together with 93 corresponding caregivers, whose burden was investigated using the Caregiver Burden Inventory. In addition, all participants were assessed for cognitive impairment, depression, anxiety, alexithymia, and HR-QoL. Only a small proportion of caregivers suffered from caregiver burden. Despite BT therapy, patients' HR-QoL was decreased compared to the age-matched general German population. Psychological symptoms, notably anxiety, and depression correlated significantly with reduced HR-QoL. Our data imply that caregiver burden emerged to be an issue in subgroups of dystonia patients. Furthermore, HR-QoL of dystonia patients is reduced even under optimized BT treatment in a specialized center.
Identifiants
pubmed: 31802240
doi: 10.1007/s00702-019-02109-6
pii: 10.1007/s00702-019-02109-6
pmc: PMC6942568
doi:
Substances chimiques
Neuromuscular Agents
0
Botulinum Toxins
EC 3.4.24.69
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
61-70Références
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