Challenging immunodominance of influenza-specific CD8


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
06 12 2019
Historique:
received: 04 06 2019
accepted: 04 11 2019
entrez: 8 12 2019
pubmed: 8 12 2019
medline: 3 3 2020
Statut: epublish

Résumé

Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease are largely unknown. As the HLA-A*68:01 allele can be linked to severe pandemic 2009-H1N1 disease, we investigate a potential impairment of HLA-A*68:01-restricted CD8

Identifiants

pubmed: 31811120
doi: 10.1038/s41467-019-13346-4
pii: 10.1038/s41467-019-13346-4
pmc: PMC6898063
doi:

Substances chimiques

Antigens, Viral 0
Epitopes, T-Lymphocyte 0
HLA-A Antigens 0
HLA-A*68 antigen 0
Nucleoproteins 0
Peptide Fragments 0
Receptors, Antigen, T-Cell, alpha-beta 0
Viral Core Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5579

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Auteurs

C E van de Sandt (CE)

Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.
Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066CX, Amsterdam, Netherlands.

E B Clemens (EB)

Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.

E J Grant (EJ)

Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.
Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Infection and Immunity Program, Monash University, Clayton, VIC, 3800, Australia.

L C Rowntree (LC)

Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.

S Sant (S)

Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.

H Halim (H)

Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.

J Crowe (J)

Deepdene Surgery, Deepdene, VIC, 3103, Australia.

A C Cheng (AC)

School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC, 3004, Australia.

T C Kotsimbos (TC)

Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, VIC, 3004, Australia.
Department of Medicine, Monash University, Central Clinical School, The Alfred Hospital, Melbourne, VIC, 3004, Australia.

M Richards (M)

Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, 3050, Australia.

A Miller (A)

Indigenous Research Network, Griffith University, Brisbane, QLD, 4222, Australia.
Office of Indigenous Engagement, CQUniversity, Townsvillle, QLD, Australia.

S Y C Tong (SYC)

Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, 3050, Australia.
Menzies School of Health Research, Charles Darwin University, Darwin, NT, 0811, Australia.

J Rossjohn (J)

Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.
Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom.

T H O Nguyen (THO)

Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.

S Gras (S)

Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.

W Chen (W)

Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Bundoora, VIC, 3086, Australia.

K Kedzierska (K)

Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia. kkedz@unimelb.edu.au.

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Classifications MeSH