The Connectivity Fingerprint of the Fusiform Gyrus Captures the Risk of Developing Autism in Infants with Tuberous Sclerosis Complex.
autism
connectivity fingerprint
fusiform gyrus
tuberous sclerosis complex
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
14 04 2020
14 04 2020
Historique:
received:
27
07
2018
revised:
05
09
2019
accepted:
12
09
2019
pubmed:
10
12
2019
medline:
19
8
2021
entrez:
9
12
2019
Statut:
ppublish
Résumé
Tuberous sclerosis complex (TSC) is a rare genetic disorder characterized by benign tumors throughout the body; it is generally diagnosed early in life and has a high prevalence of autism spectrum disorder (ASD), making it uniquely valuable in studying the early development of autism, before neuropsychiatric symptoms become apparent. One well-documented deficit in ASD is an impairment in face processing. In this work, we assessed whether anatomical connectivity patterns of the fusiform gyrus, a central structure in face processing, capture the risk of developing autism early in life. We longitudinally imaged TSC patients at 1, 2, and 3 years of age with diffusion compartment imaging. We evaluated whether the anatomical connectivity fingerprint of the fusiform gyrus was associated with the risk of developing autism measured by the Autism Observation Scale for Infants (AOSI). Our findings suggest that the fusiform gyrus connectivity captures the risk of developing autism as early as 1 year of age and provides evidence that abnormal fusiform gyrus connectivity increases with age. Moreover, the identified connections that best capture the risk of developing autism involved the fusiform gyrus and limbic and paralimbic regions that were consistent with the ASD phenotype, involving an increased number of left-lateralized structures with increasing age.
Identifiants
pubmed: 31812987
pii: 5669896
doi: 10.1093/cercor/bhz233
pmc: PMC7175001
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2199-2214Subventions
Organisme : NINDS NIH HHS
ID : U54 NS092090
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB013248
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB019483
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS082320
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090255
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS079788
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
J Neurosci. 2007 May 23;27(21):5546-58
pubmed: 17522300
Neuroimage. 2015 Aug 15;117:40-55
pubmed: 26004503
Brain. 2007 Jul;130(Pt 7):1718-31
pubmed: 17392317
Curr Opin Neurol. 2011 Apr;24(2):106-13
pubmed: 21301339
J Autism Dev Disord. 1992 Sep;22(3):339-55
pubmed: 1400103
NMR Biomed. 2017 Sep;30(9):
pubmed: 28643354
PLoS One. 2012;7(11):e48232
pubmed: 23189128
J Neurosci. 2008 May 21;28(21):5422-32
pubmed: 18495876
Magn Reson Med. 2003 Jan;49(1):177-82
pubmed: 12509835
Genes Dev. 2008 Sep 15;22(18):2485-95
pubmed: 18794346
Cell Rep. 2013 Nov 14;5(3):567-72
pubmed: 24210815
Brain Cogn. 2011 Feb;75(1):18-28
pubmed: 21055864
Mol Autism. 2014 Feb 11;5(1):11
pubmed: 24517317
Curr Opin Psychiatry. 2015 Mar;28(2):113-20
pubmed: 25602245
Cereb Cortex. 2018 Oct 1;28(10):3665-3672
pubmed: 29939236
J Child Neurol. 2004 Sep;19(9):675-9
pubmed: 15563013
J Stat Softw. 2010;33(1):1-22
pubmed: 20808728
J Neurosci. 2004 Oct 20;24(42):9228-31
pubmed: 15496656
Magn Reson Med. 2009 Sep;62(3):717-30
pubmed: 19623619
J Neurosci. 2013 Apr 17;33(16):6709-15
pubmed: 23595729
Acta Neuropathol. 2013 Mar;125(3):317-32
pubmed: 23386324
Cereb Cortex. 2007 Feb;17(2):261-71
pubmed: 16603714
Epilepsia. 2014 Apr;55(4):539-50
pubmed: 24512506
Neurosci Bull. 2017 Apr;33(2):219-237
pubmed: 28283808
Neurotherapeutics. 2015 Jul;12(3):572-83
pubmed: 25986747
Philos Trans R Soc Lond B Biol Sci. 2006 Dec 29;361(1476):2109-28
pubmed: 17118927
Neuroimage. 2017 Nov 15;162:65-72
pubmed: 28801253
PLoS Med. 2005 Aug;2(8):e124
pubmed: 16060722
Mol Autism. 2014 Oct 14;5(1):50
pubmed: 25352976
Brain. 2008 Apr;131(Pt 4):987-99
pubmed: 18332073
J Child Neurol. 2006 Mar;21(3):199-204
pubmed: 16901420
Brain. 2001 Oct;124(Pt 10):2059-73
pubmed: 11571222
Trends Cogn Sci. 2000 Jun;4(6):223-233
pubmed: 10827445
Dev Neuropsychol. 2005;27(3):403-24
pubmed: 15843104
Psychiatry Res. 2014 Nov 30;224(2):119-23
pubmed: 25159311
Neurobiol Dis. 2012 Mar;45(3):1101-10
pubmed: 22198573
J Child Psychol Psychiatry. 1978 Jul;19(3):255-68
pubmed: 681468
Neurology. 2016 Aug 23;87(8):766-72
pubmed: 27440144
Nat Neurosci. 2000 Jan;3(1):80-4
pubmed: 10607399
Pediatr Neurol. 2017 Oct;75:80-86
pubmed: 28844798
Brain. 2004 Dec;127(Pt 12):2703-16
pubmed: 15319275
J Am Acad Child Adolesc Psychiatry. 2002 Oct;41(10):1239-45
pubmed: 12364846
Cortex. 2015 Jan;62:158-81
pubmed: 25433958
Neurosci Biobehav Rev. 2012 Apr;36(4):1292-313
pubmed: 22353426
Arch Neurol. 1988 Jul;45(7):749-55
pubmed: 3260481
Future Neurol. 2013 Sep;8(5):583-597
pubmed: 24489482
Nat Neurosci. 2011 Dec 25;15(2):321-7
pubmed: 22197830
Nat Commun. 2017 Nov 7;8(1):1349
pubmed: 29116093
Biophys J. 1994 Jan;66(1):259-67
pubmed: 8130344
Arch Gen Psychiatry. 2000 Apr;57(4):331-40
pubmed: 10768694
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19067-72
pubmed: 20956328
Nat Neurosci. 2005 Dec;8(12):1727-34
pubmed: 16286931
J Neurophysiol. 2004 Sep;92(3):1830-9
pubmed: 15115795
J Child Neurol. 2008 May;23(5):520-5
pubmed: 18160549
Neuroimage. 2009 Oct 1;47(4):2005-15
pubmed: 19501175
Nat Neurosci. 2010 Feb;13(2):163-72
pubmed: 20062052
Science. 2012 Oct 5;338(6103):128-32
pubmed: 22983708
Nat Rev Neurosci. 2007 Dec;8(12):976-87
pubmed: 18026167
Mol Autism. 2015 Dec 15;6:65
pubmed: 26677408
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8135-9
pubmed: 7667258
Behav Neurosci. 2006 Feb;120(1):211-6
pubmed: 16492133
Pediatr Neurol. 2013 Oct;49(4):243-54
pubmed: 24053982
Brain. 2008 Apr;131(Pt 4):1000-12
pubmed: 18234695
Lancet Neurol. 2015 Jul;14(7):733-45
pubmed: 26067126
Acad Radiol. 2012 Jan;19(1):17-25
pubmed: 22142677
Curr Opin Neurobiol. 2005 Apr;15(2):225-30
pubmed: 15831407
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11074-9
pubmed: 20534473
Neuroimage Clin. 2012 Nov 16;2:79-94
pubmed: 24179761
Psychol Bull. 2000 May;126(3):424-53
pubmed: 10825784
Cereb Cortex. 2016 May;26(5):2046-58
pubmed: 25750257
Acta Neuropathol. 2012 May;123(5):685-93
pubmed: 22327361
Neuroimage. 2003 Oct;20(2):870-88
pubmed: 14568458
BMC Med. 2013 Feb 27;11:54
pubmed: 23445896
Brain. 2004 Aug;127(Pt 8):1811-21
pubmed: 15215213
Hum Brain Mapp. 2013 Nov;34(11):2747-66
pubmed: 22611035
Int J Dev Neurosci. 2013 Nov;31(7):667-78
pubmed: 23485365
J Clin Neurosci. 2015 Apr;22(4):664-9
pubmed: 25726458
Nat Med. 2008 Aug;14(8):843-8
pubmed: 18568033
Neuron. 2014 Oct 22;84(2):275-91
pubmed: 25374355
Eur J Paediatr Neurol. 2004;8(6):327-32
pubmed: 15542389
J Neurosci. 1997 Jun 1;17(11):4302-11
pubmed: 9151747
Neuroimage. 2014 Sep;98:266-78
pubmed: 24816531
Neurology. 2014 Jul 8;83(2):160-8
pubmed: 24920850
J Child Neurol. 2013 Dec;28(12):1569-76
pubmed: 23143725
Dev Psychobiol. 2002 Apr;40(3):213-25
pubmed: 11891634
J Autism Dev Disord. 1999 Dec;29(6):499-508
pubmed: 10638462
Hum Brain Mapp. 2017 Nov;38(11):5740-5755
pubmed: 28792117
IEEE Trans Med Imaging. 2004 Apr;23(4):447-58
pubmed: 15084070
J Child Psychol Psychiatry. 2011 Jun;52(6):631-44
pubmed: 21244421
Int J Dev Neurosci. 2005 Apr-May;23(2-3):143-52
pubmed: 15749241
Neuroimage. 2010 Apr 1;50(2):589-99
pubmed: 20026220
Cereb Cortex. 2011 May;21(5):1134-46
pubmed: 20943668
J Autism Dev Disord. 2008 Apr;38(4):731-8
pubmed: 17874180
Trends Mol Med. 2011 Feb;17(2):78-87
pubmed: 21115397
Braz J Psychiatry. 2016 Oct-Dec;38(4):267-269
pubmed: 27828560
J Clin Child Adolesc Psychol. 2019 Nov-Dec;48(6):840-854
pubmed: 29601216
J Intellect Disabil Res. 2009 Oct;53(10):852-73
pubmed: 19708861
IEEE Trans Med Imaging. 2014 Feb;33(2):504-17
pubmed: 24235301
Neuroimage. 2006 Jul 15;31(4):1614-24
pubmed: 16616862
IEEE Trans Med Imaging. 2013 Oct;32(10):1840-52
pubmed: 23744673
Nat Rev Dis Primers. 2016 May 26;2:16035
pubmed: 27226234
J Child Neurol. 2008 Mar;23(3):268-73
pubmed: 18230839
Cogn Neuropsychiatry. 2005 Jun;10(3):165-213
pubmed: 16571459
Magn Reson Med. 2013 Jun;69(6):1534-40
pubmed: 23625329
Autism Res. 2015 Feb;8(1):61-72
pubmed: 25256103
Biol Psychiatry. 2013 Aug 1;74(3):212-9
pubmed: 23375976
Med Image Anal. 2015 Dec;26(1):268-86
pubmed: 26529580
Cereb Cortex. 2015 Jun;25(6):1477-89
pubmed: 24343892
MMWR Surveill Summ. 2016 Apr 01;65(3):1-23
pubmed: 27031587
Neuroimage. 2004 Jul;22(3):1141-50
pubmed: 15219586
Neurology. 2011 Mar 15;76(11):981-7
pubmed: 21403110
Curr Opin Neurobiol. 2007 Feb;17(1):103-11
pubmed: 17275283
Magn Reson Med. 2016 Sep;76(3):963-77
pubmed: 26362832
Nature. 2007 Mar 8;446(7132):190-4
pubmed: 17322902
Pediatrics. 2017 Dec;140(6):
pubmed: 29101226
Hum Brain Mapp. 2017 Jan;38(1):509-527
pubmed: 27647682
Brain. 2002 Jun;125(Pt 6):1247-55
pubmed: 12023313
Hum Brain Mapp. 2003 Apr;18(4):306-21
pubmed: 12632468
Cereb Cortex. 2013 Jul;23(7):1526-32
pubmed: 22661408
AJNR Am J Neuroradiol. 2007 Oct;28(9):1662-7
pubmed: 17893226
Pediatr Neurol. 2010 Feb;42(2):101-6
pubmed: 20117745
Neuroimage. 2018 Apr 1;169:524-539
pubmed: 29258891
Neuroradiology. 2009 Nov;51(11):781-6
pubmed: 19603155
Genes Brain Behav. 2003 Oct;2(5):255-67
pubmed: 14606691