Effect of magnesium supplementation on lactate clearance in critically ill patients with severe sepsis: a randomized clinical trial.
Lactate
Lactate clearance
Magnesium
Sepsis
Severe sepsis
Journal
European journal of clinical pharmacology
ISSN: 1432-1041
Titre abrégé: Eur J Clin Pharmacol
Pays: Germany
ID NLM: 1256165
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
22
03
2019
accepted:
25
10
2019
pubmed:
10
12
2019
medline:
2
10
2020
entrez:
10
12
2019
Statut:
ppublish
Résumé
In this study, changes in lactate clearance following magnesium supplementation were evaluated in critically ill patients with severe sepsis. Fifty-eight patients with severe sepsis were randomly assigned to receive either magnesium (n = 30) or placebo (n = 28). Patients in the magnesium group received intravenous magnesium sulfate to maintain serum magnesium level around 3 mg/dL for 3 days. The placebo group received the same volume of normal saline. Change in lactate clearance was considered primary outcome of the study. Mean increase in the lactate clearance in the magnesium group was significantly higher than the placebo group on day 2 (27.53% vs. 23.79% respectively, p < 0.001) and day 3 (49.83% vs. 37.02% respectively, p < 0.001). Time to lactate clearance was also significantly shorter in the magnesium group than the placebo group (47.28 ± 20.59 vs. 61.20 ± 24.31 h respectively, p = 0.03). Sepsis-related mortality was not significantly different but median length of ICU stay was significantly shorter in the magnesium group than the placebo group (8 vs. 15 days respectively, p < 0.01). Magnesium supplementation increased lactate clearance in critically ill patients with severe sepsis. Optimizing serum magnesium level near the upper limit of the normal range may improve severe sepsis outcomes.
Identifiants
pubmed: 31814044
doi: 10.1007/s00228-019-02788-w
pii: 10.1007/s00228-019-02788-w
doi:
Substances chimiques
Lactic Acid
33X04XA5AT
Magnesium Sulfate
7487-88-9
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-184Références
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