Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of
ShSPI
centipede
human neutrophils elastase
kazal-type inhibitor
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
05 12 2019
05 12 2019
Historique:
received:
07
11
2019
revised:
26
11
2019
accepted:
03
12
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
27
10
2020
Statut:
epublish
Résumé
Elastase is a globular glycoprotein and belongs to the chymotrypsin family. It is involved in several inflammatory cascades on the basis of cleaving the important connective tissue protein elastin, and is strictly regulated to a balance by several endogenous inhibitors. When elastase and its inhibitors are out of balance, severe diseases will develop, especially those involved in the cardiopulmonary system. Much attention has been attracted in seeking innovative elastase inhibitors and various advancements have been taken on clinical trials of these inhibitors. Natural functional peptides from venomous animals have been shown to have anti-protease properties. Here, we identified a kazal-type serine protease inhibitor named ShSPI from the cDNA library of the venom glands of
Identifiants
pubmed: 31817486
pii: toxins11120708
doi: 10.3390/toxins11120708
pmc: PMC6950245
pii:
doi:
Substances chimiques
Arthropod Venoms
0
Serine Proteinase Inhibitors
0
Pancreatic Elastase
EC 3.4.21.36
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Nat Commun. 2015 Sep 30;6:8297
pubmed: 26420335
J Pharmacol Exp Ther. 2011 Oct;339(1):313-20
pubmed: 21791628
Ther Clin Risk Manag. 2014 Aug 05;10:621-9
pubmed: 25120368
Pediatr Int. 2019 May;61(5):438-443
pubmed: 30916859
PLoS One. 2013;8(1):e53343
pubmed: 23308198
Shock. 2010 May;33(5):526-31
pubmed: 19953005
Comp Biochem Physiol B Biochem Mol Biol. 2013 May;165(1):36-41
pubmed: 23499942
Intern Med. 2010;49(22):2423-32
pubmed: 21088343
Int J Biol Macromol. 2015 Jan;72:158-62
pubmed: 25150597
J Synchrotron Radiat. 2008 May;15(Pt 3):308-11
pubmed: 18421166
Curr Heart Fail Rep. 2015 Apr;12(2):130-40
pubmed: 25475180
J Magn Reson. 1997 Dec;129(2):125-9
pubmed: 9441876
EBioMedicine. 2016 Nov;13:248-261
pubmed: 27887936
Sci Rep. 2017 Nov 22;7(1):16032
pubmed: 29167482
Protein Sci. 2018 Jan;27(1):293-315
pubmed: 29067766
Int J Pept Res Ther. 2013;19:303-311
pubmed: 24273471
Am J Pathol. 2010 Oct;177(4):1665-73
pubmed: 20709801
Mol Cell Proteomics. 2012 Sep;11(9):640-50
pubmed: 22595790
Toxicon. 2009 Jul;54(1):8-15
pubmed: 19285520
Am J Respir Crit Care Med. 2000 Jun;161(6):2013-8
pubmed: 10852782
Thromb Haemost. 2017 Jun 2;117(6):1031-1039
pubmed: 28276572
J Biol Chem. 1995 Jun 9;270(23):13879-84
pubmed: 7775446
Annu Rev Genomics Hum Genet. 2009;10:483-511
pubmed: 19640225
Dev Comp Immunol. 2016 Oct;63:27-35
pubmed: 27208884
Am J Respir Crit Care Med. 2015 Jun 1;191(11):1226-31
pubmed: 26029837
Curr Opin Struct Biol. 2003 Feb;13(1):130-9
pubmed: 12581670
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1646-1651
pubmed: 29358396
Toxicon. 2018 Mar 1;143:96-107
pubmed: 29360533
Biochemistry. 2005 Jul 19;44(28):9626-36
pubmed: 16008348
Toxicol In Vitro. 2015 Oct;29(7):1569-76
pubmed: 26100226
Eur Respir J. 2012 Dec;40(6):1475-82
pubmed: 22441751
PLoS Pathog. 2018 Feb 9;14(2):e1006870
pubmed: 29425229
J Proteome Res. 2012 Dec 7;11(12):6197-212
pubmed: 23148443
BMC Biochem. 2005 Aug 23;6:15
pubmed: 16117831
J Biomol NMR. 1995 Nov;6(3):277-93
pubmed: 8520220
J Cell Biochem. 2019 Sep;120(9):14594-14603
pubmed: 31016790
Toxicon. 2015 Nov;106:7-13
pubmed: 26363290
Toxins (Basel). 2018 Oct 26;10(11):null
pubmed: 30373118
Methods Mol Biol. 2017;1627:1-23
pubmed: 28836191
J Proteomics. 2015 Jan 30;114:28-37
pubmed: 25449838
J Magn Reson. 2003 Jan;160(1):65-73
pubmed: 12565051
Toxins (Basel). 2016 Oct 05;8(10):
pubmed: 27782050
Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20
pubmed: 2049103
Biochem Biophys Res Commun. 1967 Apr 20;27(2):157-62
pubmed: 6035483
Int Rev Immunol. 2014 Nov-Dec;33(6):498-510
pubmed: 24611785