Gorgan (Iran) population HLA genetics and anthropology.
Altai
Chuvash
Gorgan
HLA
Iran
Kurgan
Persia
Sarmatian
Scythian
Siberia
Turkmen
Tuvinian
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
16
10
2019
revised:
25
11
2019
accepted:
26
11
2019
pubmed:
11
12
2019
medline:
3
10
2020
entrez:
11
12
2019
Statut:
ppublish
Résumé
Gorgan (Iran) have been studied for HLA-A, -B, -C, -DRB1 and -DQB1 genes for the first time. They are Turkmen and originated in East Asia around Altai Mts; they originally spoke a Turk language classified within the Turkish-Oguz group. Peripheral blood samples were collected from Gorgan City (Iran) and HLA typed by standard methodology. HLA allele frequencies were compared with 7984 chromosomes of other World populations and it was shown existence of admixture of Siberian and Mediterranean HLA characters in this population, probably due to longlasting contact with Persians. Three new HLA extended haplotypes were found: A*01:01-B*35:01-DRB1*03:01-DQB1*02:01, A*30:01-B*13:01-DRB1*15:01-DQB1*02:01 and A*31:01-B*35:01-DRB1*15:01-DQB1*03:01. Gorgan (Iran) were most close to Chuvashians (Noth Caspian Sea, Russia) and Siberians, like Tuvinians, Mansi and Buryats in Neighbour Joining and Vista analyses. It is established a relationship of this population with Kurgan (Gorgan, Iran) archaeological mounds culture. However, their kinship with Scythians (2nd century BC) and Sarmatians (4th century AD) is obscure although both of them spoke a Persian language.
Identifiants
pubmed: 31818457
pii: S0198-8859(19)31290-X
doi: 10.1016/j.humimm.2019.11.009
pii:
doi:
Substances chimiques
HLA Antigens
0
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-11Informations de copyright
Copyright © 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.