Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis.
IL-27 receptor
WSX-1
inflammation
interleukin-27
macrophages
neonatal
phagocytes
sepsis
Journal
Infection and immunity
ISSN: 1098-5522
Titre abrégé: Infect Immun
Pays: United States
ID NLM: 0246127
Informations de publication
Date de publication:
20 02 2020
20 02 2020
Historique:
received:
29
10
2019
accepted:
22
11
2019
pubmed:
11
12
2019
medline:
24
4
2020
entrez:
11
12
2019
Statut:
epublish
Résumé
Neonates are at increased risk for bacterial sepsis. We established that the immune-suppressive cytokine interleukin-27 (IL-27) is elevated in neonatal mice. Similarly, human cord blood-derived macrophages express IL-27 genes and secrete more cytokine than macrophages from adults. In the present work, we hypothesized that increased levels of IL-27 predispose neonatal mice to more severe infection during Gram-negative sepsis. Serum IL-27 levels continued to rise during infection. Peripheral tissue analysis revealed systemic IL-27 expression, while myeloid cell profiling identified Gr-1- and F4/80-expressing cells as the most abundant producers of IL-27 during infection. Increased IL-27 levels were consistent with increased mortality that was improved in IL-27 receptor α (IL-27Rα)
Identifiants
pubmed: 31818960
pii: IAI.00828-19
doi: 10.1128/IAI.00828-19
pmc: PMC7035946
pii:
doi:
Substances chimiques
Interleukin-27
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Seman et al.
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