Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis.
Adolescent
Adult
Aged
Alarmins
/ genetics
Anti-Inflammatory Agents, Non-Steroidal
/ therapeutic use
Biopsy
Cell Line
Colitis, Ulcerative
/ drug therapy
Female
Gene Expression Regulation
/ drug effects
Humans
Immunosuppressive Agents
/ therapeutic use
Interleukin-33
/ genetics
Intestinal Mucosa
/ immunology
Male
Metabolic Networks and Pathways
MicroRNAs
/ genetics
Middle Aged
RNA Interference
RNA, Messenger
/ genetics
Signal Transduction
Tumor Necrosis Factor-alpha
/ metabolism
Young Adult
IBD
IL-33
PPARGC1B
alarmin
miR-378a-3p
microRNA
microRNA family
ulcerative colitis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
07
2019
accepted:
01
10
2019
entrez:
12
12
2019
pubmed:
12
12
2019
medline:
11
11
2020
Statut:
epublish
Résumé
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by mucosa damage associated with an uncontrolled inflammatory response. This immunological impairment leads to altered inflammatory mediators such as IL-33, which is shown to increase in the mucosa of active UC (aUC) patients. MicroRNAs present a distorted feature in inflamed colonic mucosa and are potential IL-33 regulating candidates in UC. Therefore, we studied the microRNA and mRNA profiles in inflamed colonic samples of UC patients, evaluating the effect of a microRNA (selected by
Identifiants
pubmed: 31824476
doi: 10.3389/fimmu.2019.02449
pmc: PMC6879552
doi:
Substances chimiques
Alarmins
0
Anti-Inflammatory Agents, Non-Steroidal
0
IL33 protein, human
0
Immunosuppressive Agents
0
Interleukin-33
0
MIRN378 microRNA, human
0
MicroRNAs
0
RNA, Messenger
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2449Informations de copyright
Copyright © 2019 Dubois-Camacho, Diaz-Jimenez, De la Fuente, Quera, Simian, Martínez, Landskron, Olivares-Morales, Cidlowski, Xu, Gao, Xie, Chnaiderman, Soto-Rifo, González, Calixto and Hermoso.
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