Effects of Angiotensin-(1-7) and Angiotensin II on Acetylcholine-Induced Vascular Relaxation in Spontaneously Hypertensive Rats.
Acetylcholine
/ toxicity
Angiotensin I
/ pharmacology
Angiotensin II
/ pharmacology
Animals
Blood Pressure
/ drug effects
Cyclic GMP
/ metabolism
Cyclic GMP-Dependent Protein Kinases
/ metabolism
Hypertension
/ chemically induced
Male
Nitric Oxide
/ metabolism
Peptide Fragments
/ pharmacology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Vasodilation
/ drug effects
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
04
2019
revised:
22
07
2019
accepted:
12
08
2019
entrez:
13
12
2019
pubmed:
13
12
2019
medline:
6
5
2020
Statut:
epublish
Résumé
Endothelial dysfunction of small arteries occurs in patients with hypertension and in various hypertensive models. Endothelial function is usually evaluated by the degree of acetylcholine- (ACh-) induced vascular relaxation. Our previous study has found that compared to Wistar-Kyoto rats (WKY), ACh-induced vasodilatation was attenuated significantly in the mesenteric artery (MA), coronary artery (CA), and pulmonary artery (PA) of spontaneously hypertensive rats (SHR). This study investigated the influence of angiotensin- (Ang-) (1-7) and Ang II on blood pressure and ACh-induced vascular relaxation, as well as their interactive roles and downstream signal pathways in SHR and WKY. Intravenous injection of Ang II significantly increased, while Ang-(1-7) decreased the mean arterial pressure (MAP) in SHR. Ang-(1-7) improved ACh-induced relaxation in the MA, CA, and PA of SHR, while Ang II further attenuated it, which were inhibited by pretreatment with Mas receptor antagonist A-779 or AT
Identifiants
pubmed: 31827689
doi: 10.1155/2019/6512485
pmc: PMC6886389
doi:
Substances chimiques
Peptide Fragments
0
Angiotensin II
11128-99-7
Nitric Oxide
31C4KY9ESH
Angiotensin I
9041-90-1
Cyclic GMP-Dependent Protein Kinases
EC 2.7.11.12
Cyclic GMP
H2D2X058MU
angiotensin I (1-7)
IJ3FUK8MOF
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6512485Informations de copyright
Copyright © 2019 Feng Zhang et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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