High-order interactions distort the functional landscape of microbial consortia.
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
30
01
2019
accepted:
15
11
2019
revised:
26
12
2019
pubmed:
13
12
2019
medline:
21
3
2020
entrez:
13
12
2019
Statut:
epublish
Résumé
Understanding the link between community composition and function is a major challenge in microbial population biology, with implications for the management of natural microbiomes and the design of synthetic consortia. Specifically, it is poorly understood whether community functions can be quantitatively predicted from traits of species in monoculture. Inspired by the study of complex genetic interactions, we have examined how the amylolytic rate of combinatorial assemblages of six starch-degrading soil bacteria depend on the separate functional contributions from each species and their interactions. Filtering our results through the theory of biochemical kinetics, we show that this simple function is additive in the absence of interactions among community members. For about half of the combinatorially assembled consortia, the amylolytic function is dominated by pairwise and higher-order interactions. For the other half, the function is additive despite the presence of strong competitive interactions. We explain the mechanistic basis of these findings and propose a quantitative framework that allows us to separate the effect of behavioral and population dynamics interactions. Our results suggest that the functional robustness of a consortium to pairwise and higher-order interactions critically affects our ability to predict and bottom-up engineer ecosystem function in complex communities.
Identifiants
pubmed: 31830028
doi: 10.1371/journal.pbio.3000550
pii: PBIOLOGY-D-19-00270
pmc: PMC6932822
doi:
Substances chimiques
Soil
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3000550Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM133467
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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