Succinate detection using in vivo
Magnetic resonance spectroscopy
Paraganglioma
Succinate
Succinate dehydrogenase
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
21
08
2019
accepted:
19
11
2019
pubmed:
14
12
2019
medline:
15
5
2021
entrez:
14
12
2019
Statut:
ppublish
Résumé
Germline mutations in genes encoding succinate dehydrogenase (SDH) are frequent in patients with pheochromocytoma and paraganglioma (PPGL). They lead to SDH inactivation, mediating a massive accumulation of succinate, which constitutes a highly specific biomarker of SDHx-mutated tumors when measured in vitro. In a recent pilot study, we showed that magnetic resonance spectroscopy ( Forty-nine patients presenting with 50 PPGLs were prospectively enrolled in our referral center for A succinate peak was observed in 20 tumors, all of which had proven SDH deficiency using the gold standard (17 patients with germline SDHx mutations, 2 with a somatic SDHD mutation, and 1 with negative SDHB IHC and SDH loss of function). A false negative result was observed in 3 tumors. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of Detection of succinate using
Identifiants
pubmed: 31834447
doi: 10.1007/s00259-019-04633-9
pii: 10.1007/s00259-019-04633-9
doi:
Substances chimiques
Succinic Acid
AB6MNQ6J6L
Succinate Dehydrogenase
EC 1.3.99.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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