Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer.
GTPase Kras (KRAS)
GTPase-activating protein (GAP)
NF1
Ras protein
cancer
cell signaling
dimerization
mitogen-activated protein kinase pathway
neurofibromin
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
24 01 2020
24 01 2020
Historique:
received:
03
09
2019
revised:
10
12
2019
pubmed:
15
12
2019
medline:
5
9
2020
entrez:
15
12
2019
Statut:
ppublish
Résumé
Neurofibromin is a tumor suppressor encoded by the
Identifiants
pubmed: 31836666
pii: S0021-9258(17)49919-4
doi: 10.1074/jbc.RA119.010934
pmc: PMC6983858
doi:
Substances chimiques
Neurofibromin 1
0
ras GTPase-Activating Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1105-1119Subventions
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197709
Pays : United States
Informations de copyright
© 2020 Sherekar et al.
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