Epicardial and subcutaneous adipose tissue in Indigenous and non-Indigenous individuals: Implications for cardiometabolic diseases.
Adult
Australia
/ ethnology
Body Mass Index
Cardiometabolic Risk Factors
Coronary Angiography
Female
Humans
Male
Metabolic Syndrome
/ ethnology
Middle Aged
Multidetector Computed Tomography
Native Hawaiian or Other Pacific Islander
/ statistics & numerical data
Pericardium
/ diagnostic imaging
Subcutaneous Fat
/ diagnostic imaging
White People
/ statistics & numerical data
Epicardial fat
Indigenous
Obesity
Visceral fat
Journal
Obesity research & clinical practice
ISSN: 1871-403X
Titre abrégé: Obes Res Clin Pract
Pays: Netherlands
ID NLM: 101303911
Informations de publication
Date de publication:
Historique:
received:
18
11
2019
revised:
07
12
2019
accepted:
07
12
2019
pubmed:
17
12
2019
medline:
23
1
2021
entrez:
17
12
2019
Statut:
ppublish
Résumé
Obesity is prevalent in Indigenous populations who exhibit significant differences in body fat composition. While excess regional adiposity can be partially inferred from clinical measurements, noninvasive imaging allows for direct quantification of specific fat depots. Epicardial fat is a visceral adipose tissue that has been strongly associated with cardiometabolic disease in other populations. However, this ectopic fat depot has yet to be characterized in Indigenous populations. We studied 100 individuals matched for ethnicity (Indigenous Australian and Caucasian descent), age, gender, and body mass index. Epicardial and subcutaneous adipose tissue volumes was quantified with computed tomography. Associations of ethnicity and adiposity measures were assessed using linear regression. Indigenous individuals had significantly greater epicardial fat volumes compared to non-Indigenous individuals (95.8±37.5 vs 54.1±27.6cm Indigenous individuals have significantly greater epicardial fat, but similar subcutaneous fat volumes, compared to non-Indigenous individuals. This finding extends previous observations on body fat composition differences in these individuals, and supports the possibility that epicardial fat and other visceral adipose depots may be contributing to the greater burden of cardiovascular disease in Indigenous populations.
Sections du résumé
BACKGROUND
Obesity is prevalent in Indigenous populations who exhibit significant differences in body fat composition. While excess regional adiposity can be partially inferred from clinical measurements, noninvasive imaging allows for direct quantification of specific fat depots. Epicardial fat is a visceral adipose tissue that has been strongly associated with cardiometabolic disease in other populations. However, this ectopic fat depot has yet to be characterized in Indigenous populations.
METHODS
We studied 100 individuals matched for ethnicity (Indigenous Australian and Caucasian descent), age, gender, and body mass index. Epicardial and subcutaneous adipose tissue volumes was quantified with computed tomography. Associations of ethnicity and adiposity measures were assessed using linear regression.
RESULTS
Indigenous individuals had significantly greater epicardial fat volumes compared to non-Indigenous individuals (95.8±37.5 vs 54.1±27.6cm
CONCLUSIONS
Indigenous individuals have significantly greater epicardial fat, but similar subcutaneous fat volumes, compared to non-Indigenous individuals. This finding extends previous observations on body fat composition differences in these individuals, and supports the possibility that epicardial fat and other visceral adipose depots may be contributing to the greater burden of cardiovascular disease in Indigenous populations.
Identifiants
pubmed: 31839475
pii: S1871-403X(19)30698-2
doi: 10.1016/j.orcp.2019.12.001
pii:
doi:
Types de publication
Comparative Study
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-102Informations de copyright
Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.