Elucidation of cGMP-dependent induction of mitochondrial biogenesis through PKG and p38 MAPK in the kidney.
Animals
Carbazoles
/ pharmacology
Cells, Cultured
Cyclic GMP
/ metabolism
Cyclic GMP-Dependent Protein Kinases
/ antagonists & inhibitors
Dibenzocycloheptenes
/ pharmacology
Enzyme Activation
Enzyme Activators
/ pharmacology
Female
Fluorobenzenes
/ pharmacology
Formoterol Fumarate
/ pharmacology
Kidney
/ drug effects
Mitochondria
/ drug effects
Organelle Biogenesis
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ metabolism
Phosphorylation
Protein Kinase Inhibitors
/ pharmacology
Pyrazoles
/ pharmacology
Pyrimidines
/ pharmacology
Rabbits
Signal Transduction
p38 Mitogen-Activated Protein Kinases
/ antagonists & inhibitors
biogenesis
cGMP
guanylyl cyclase
mitochondria
mitogen-activated protein kinase
protein kinase G
renal repair
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
pubmed:
17
12
2019
medline:
12
5
2020
entrez:
17
12
2019
Statut:
ppublish
Résumé
Previous studies have shown that cGMP increases mitochondrial biogenesis (MB). Our laboratory has determined that formoterol and LY344864, agonists of the β
Identifiants
pubmed: 31841384
doi: 10.1152/ajprenal.00533.2019
pmc: PMC7052650
doi:
Substances chimiques
Carbazoles
0
Dibenzocycloheptenes
0
Enzyme Activators
0
Fluorobenzenes
0
LY 344864
0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Protein Kinase Inhibitors
0
Pyrazoles
0
Pyrimidines
0
skepinone-L
0
KT 5823
126643-37-6
Cyclic GMP-Dependent Protein Kinases
EC 2.7.11.12
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Cyclic GMP
H2D2X058MU
riociguat
RU3FE2Y4XI
Formoterol Fumarate
W34SHF8J2K
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
F322-F328Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES006694
Pays : United States
Références
Sci Signal. 2009 Dec 01;2(99):ra78
pubmed: 19952371
Am J Clin Nutr. 2011 Apr;93(4):884S-90
pubmed: 21289221
Nat Med. 2013 Oct;19(10):1252-63
pubmed: 24100998
J Pharmacol Exp Ther. 2013 Dec;347(3):626-34
pubmed: 24042162
P T. 2014 Nov;39(11):749-58
pubmed: 25395817
Nitric Oxide. 2007 Feb;16(1):10-7
pubmed: 17049286
J Biol Chem. 2005 Jan 7;280(1):1-4
pubmed: 15545263
Nat Chem Biol. 2011 Dec 25;8(2):141-3
pubmed: 22198732
Science. 2003 Feb 7;299(5608):896-9
pubmed: 12574632
J Biol Chem. 2007 Jan 26;282(4):2355-62
pubmed: 17116659
Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16507-12
pubmed: 15545607
Curr Opin Pharmacol. 2015 Apr;21:95-104
pubmed: 25645316
Genes Dev. 2002 Mar 1;16(5):533-47
pubmed: 11877373
Blood. 2006 Feb 1;107(3):965-72
pubmed: 16210341
Essays Biochem. 2010;47:69-84
pubmed: 20533901
Nat Rev Endocrinol. 2014 Mar;10(3):157-63
pubmed: 24296515
Cell. 1998 Mar 20;92(6):829-39
pubmed: 9529258
J Clin Invest. 2012 Mar;122(3):1022-36
pubmed: 22307324
Br J Pharmacol. 2011 Mar;162(5):1213-24
pubmed: 21108628
Am J Physiol Renal Physiol. 2013 Sep 15;305(6):F881-90
pubmed: 23825069
Curr Heart Fail Rep. 2011 Mar;8(1):38-44
pubmed: 21207207
Sci Rep. 2017 Sep 5;7(1):10578
pubmed: 28874749
J Biol Chem. 2000 Jan 28;275(4):2811-6
pubmed: 10644746
Pharmacol Rev. 2010 Sep;62(3):525-63
pubmed: 20716671
Mol Cell. 2001 Nov;8(5):971-82
pubmed: 11741533
Am J Physiol. 1996 Dec;271(6 Pt 1):C2072-80
pubmed: 8997210
Diabetes. 2008 Aug;57(8):2028-36
pubmed: 18477809
Life Sci. 2007 Aug 2;81(8):640-6
pubmed: 17707440
Handb Exp Pharmacol. 2017;243:225-247
pubmed: 27900610
Am J Physiol Renal Physiol. 2018 Feb 1;314(2):F260-F268
pubmed: 29046298
Genes Dev. 2008 Apr 1;22(7):832-53
pubmed: 18381888