Pharmaceutical Development and Safety Evaluation of a GMP-Grade Fucoidan for Molecular Diagnosis of Cardiovascular Diseases.
Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Development
Female
Male
Molecular Weight
Myocardial Reperfusion Injury
/ diagnostic imaging
P-Selectin
/ metabolism
Polysaccharides
/ administration & dosage
Radiopharmaceuticals
/ administration & dosage
Rats
Rats, Wistar
Swine
Technetium
/ administration & dosage
GMP-grade fucoidan
molecular diagnosis
regulatory toxicology
scintigraphy
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
12 Dec 2019
12 Dec 2019
Historique:
received:
15
11
2019
revised:
04
12
2019
accepted:
09
12
2019
entrez:
18
12
2019
pubmed:
18
12
2019
medline:
14
5
2020
Statut:
epublish
Résumé
The adhesion molecule P-selectin is present on the cell surface of both activated endothelium and activated platelets. The present study describes the pharmaceutical development, safety evaluation, and preclinical efficacy of a micro-dosed radiotracer. The macromolecular nanoscale assembly consisted of a natural compound made of a sulfated fucose-rich polysaccharides (fucoidan) and a radionuclide (technetium-99m) for the detection of
Identifiants
pubmed: 31842319
pii: md17120699
doi: 10.3390/md17120699
pmc: PMC6949921
pii:
doi:
Substances chimiques
P-Selectin
0
Polysaccharides
0
Radiopharmaceuticals
0
Technetium
7440-26-8
fucoidan
9072-19-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : FP7 Health
ID : FP7-NMP-2012-LARGE-6-309820
Organisme : ANR
ID : ANR-13-LAB1-0005-01
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