Structure of Urocanate Hydratase from the protozoan Trypanosoma cruzi.

Amino Acid Sequence Bacillus subtilis / enzymology Cloning, Molecular Crystallization Geobacillus / enzymology Histidine NAD / ultrastructure Protein Conformation, alpha-Helical Pseudomonas putida / enzymology Reproducibility of Results Sequence Alignment Trypanosoma cruzi / enzymology Urocanate Hydratase / ultrastructure
Chagas disease Histidine metabolism Human Urocanate Hydratase deleterious mutations Interdomain movement Trypanosoma cruzi Urocanate Hydratase

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 Mar 2020
Historique:
received: 05 10 2019
revised: 12 12 2019
accepted: 12 12 2019
pubmed: 18 12 2019
medline: 15 12 2020
entrez: 18 12 2019
Statut: ppublish

Résumé

The enzyme Urocanate Hydratase (UH) participates in the catabolic pathway of L-histidine. Trypanosoma cruzi Urocanate Hydratase (TcUH) is identified as a therapeutic molecular target in the WHO/TDR Targets Database. We report the 3D structure determination and number of features of TcUH, and compared it to other few available bacterial UH structures. Each monomer presents two domains and one NAD

Identifiants

DOI: 10.1016/j.ijbiomac.2019.12.101 PMID: 31843618
pubmed: 31843618
pii: S0141-8130(19)38046-8
doi: 10.1016/j.ijbiomac.2019.12.101
pii:
doi:

Substances chimiques

NAD 0U46U6E8UK
Histidine 4QD397987E
Urocanate Hydratase EC 4.2.1.49

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

716-724

Subventions

Organisme : Medical Research Council
ID : MR/P027989/1
Pays : United Kingdom

Informations de copyright

Copyright © 2019. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no competing interests.

Auteurs

Sheila Boreiko (S)

Department of Chemistry, State University of Ponta Grossa, Ponta Grossa, PR 84030-900, Brazil.

Marcio Silva (M)

Department of Education, Federal Technological University of Paraná, Ponta Grossa, PR 84016-210, Brazil.

Raíssa de F P Melo (R)

Laboratory of Biochemistry of Tryps - LaBTryps - Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.

Ariel M Silber (AM)

Laboratory of Biochemistry of Tryps - LaBTryps - Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.

Jorge Iulek (J)

Department of Chemistry, State University of Ponta Grossa, Ponta Grossa, PR 84030-900, Brazil. Electronic address: iulek@uepg.br.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Bacillaceae › Bacillus › Bacillus subtilis › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Clonage moléculaire › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Phénomènes chimiques › Cristallisation › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Bacillaceae › Geobacillus › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Histidine › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Structure en hélice alpha › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas putida › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Alignement de séquences › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma cruzi › Structure of Urocanate Hydratase from the...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Urocanate hydratase › Structure of Urocanate Hydratase from the...